Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual oxidase homolog | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.017 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.017 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.017 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.017 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.017 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0 | 0.5 |
Onchocerca volvulus | 0.017 | 0 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 62.2 nmol | Inhibition of protoporphyrinogen IX oxidase in Scenedesmus acutus assessed as protoporphyrin IX level per ml of packed cell volume at 1 uM after 1 hr by HPLC | ChEMBL. | No reference |
IC50 (binding) | = 7.07 | Inhibition of protoporphyrinogen IX oxidase in Zea mays cv | LITERATURE. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.