Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0118568 | 0.0402175 | 0.017362 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00961129 | 0.0252392 | 0.00202698 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.00961129 | 0.0252392 | 0.13218 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.155745 | 1 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.00931448 | 0.0232594 | 0.0152836 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.01156 | 0.0382377 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.00931448 | 0.0232594 | 0.608284 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0644637 | 0.391123 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.00931448 | 0.0232594 | 0.0152836 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.00931448 | 0.0232594 | 0.0152836 |
Loa Loa (eye worm) | hypothetical protein | 0.00961129 | 0.0252392 | 0.660061 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.01156 | 0.0382377 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00931448 | 0.0232594 | 0.02366 |
Schistosoma mansoni | hypothetical protein | 0.0912815 | 0.570006 | 0.559766 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.00704176 | 0.00809958 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.01156 | 0.0382377 | 0.0303842 |
Echinococcus granulosus | voltage gated potassium channel | 0.00961129 | 0.0252392 | 0.0172796 |
Echinococcus multilocularis | hypothetical protein | 0.0912815 | 0.570006 | 0.566495 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.155745 | 1 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.00931448 | 0.0232594 | 0.608284 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00961129 | 0.0252392 | 0.00202698 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00961129 | 0.0252392 | 0.0172796 |
Echinococcus multilocularis | voltage gated potassium channel | 0.00961129 | 0.0252392 | 0.0172796 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.155745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00931448 | 0.0232594 | 0.608284 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00961129 | 0.0252392 | 0.0172796 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.00931448 | 0.0232594 | 0.0152836 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.155745 | 1 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.155745 | 1 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.155745 | 1 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.155745 | 1 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.155745 | 1 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.00931448 | 0.0232594 | 0.0152836 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.01156 | 0.0382377 | 0.0303842 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0608817 | 0.36723 | 0.352161 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0118568 | 0.0402175 | 0.017362 |
Echinococcus granulosus | Ion_trans_N domain containing protein | 0.0912815 | 0.570006 | 0.566495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.1 nM | Antimalarial activity against the chloroquine sensitive NF54 strain of Plasmodium falciparum | ChEMBL. | 9925735 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 9925735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.