Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0386 | 0.0443 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.1821 | 0.4767 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1821 | 0.4767 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2417 | 0.2777 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.712 | 0.818 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0386 | 0.0443 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0386 | 0.101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.1821 | 0.4767 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1289 | 0.3374 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.1821 | 0.4767 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1821 | 0.4767 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0386 | 0.101 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0386 | 0.101 |
Loa Loa (eye worm) | p25-alpha family protein | 0.0375 | 0.8704 | 1 |
Brugia malayi | p25-alpha family protein | 0.0375 | 0.8704 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0386 | 0.101 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0386 | 0.101 |
Echinococcus granulosus | geminin | 0.0174 | 0.3819 | 1 |
Brugia malayi | hypothetical protein | 0.031 | 0.712 | 0.818 |
Onchocerca volvulus | TPPP family protein homolog | 0.0375 | 0.8704 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 0.3819 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0386 | 0.0443 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0386 | 0.101 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.2067 | 0.2375 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.2067 | 0.2375 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.3819 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.2067 | 0.2375 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1289 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2067 | 0.2375 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.3819 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.1821 | 0.2092 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0386 | 0.101 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.1821 | 0.2092 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0386 | 0.101 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2417 | 0.2777 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0386 | 0.0443 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0386 | 0.101 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0386 | 0.101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.1821 | 0.4767 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.1821 | 0.4767 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.1289 | 0.1481 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2417 | 0.2777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.