Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) | 15-cis-phytoene desaturase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible oxidoreductase | Get druggable targets OG5_136205 | All targets in OG5_136205 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell adhesion molecule | 0.0093 | 0.0047 | 0.0054 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1001 | 0.8674 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1001 | 0.8674 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0558 | 0.4472 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1065 | 0.9287 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0322 | 0.2222 | 0.2561 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0093 | 0.0047 | 0.0054 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0322 | 0.2222 | 0.2561 |
Schistosoma mansoni | tyrosine kinase | 0.053 | 0.4206 | 0.4849 |
Schistosoma mansoni | tyrosine kinase | 0.0539 | 0.4286 | 0.4942 |
Schistosoma mansoni | tyrosine kinase | 0.0539 | 0.4286 | 0.4942 |
Echinococcus multilocularis | roundabout 2 | 0.0111 | 0.0217 | 0.025 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0539 | 0.4286 | 0.4942 |
Schistosoma mansoni | tyrosine kinase | 0.053 | 0.4206 | 0.4849 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0322 | 0.2222 | 0.2185 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0539 | 0.4286 | 0.4942 |
Schistosoma mansoni | tyrosine kinase | 0.053 | 0.4206 | 0.4849 |
Schistosoma mansoni | tyrosine kinase | 0.0322 | 0.2222 | 0.2561 |
Echinococcus granulosus | roundabout 2 | 0.0111 | 0.0217 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0217 | 0.0171 |
Schistosoma mansoni | tyrosine kinase | 0.1001 | 0.8674 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0322 | 0.2222 | 0.2561 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1001 | 0.8674 | 0.8668 |
Echinococcus granulosus | insulin receptor | 0.0322 | 0.2222 | 0.2561 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0322 | 0.2222 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0217 | 0.0171 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1001 | 0.8674 | 0.8295 |
Echinococcus multilocularis | 0.0309 | 0.21 | 0.2421 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0539 | 0.4286 | 0.4942 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.114 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 4 | Inhibition of Capsicum annuum (pepper) zeta-carotene desaturase expressed in Escherichia coli using zeta-carotene as substrate after 8 hr by Dixon plot analysis | ChEMBL. | 12720390 |
IC50 (binding) | = 6.5 | Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichia coli JM101 using phytoene as substrate after 8 hr by Dixon plot analysis | ChEMBL. | 12720390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.