Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Nicotiana tabacum | Protoporphyrinogen oxidase, chloroplastic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Neospora caninum | Protoporphyrinogen oxidase, related | Protoporphyrinogen oxidase, chloroplastic | 548 aa | 482 aa | 23.4 % |
Toxoplasma gondii | protoporphyrinogen oxidase | Protoporphyrinogen oxidase, chloroplastic | 548 aa | 467 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.041 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.041 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.041 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.2859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 0.3601 | 0.5 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 0.3601 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.041 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0167 | 0.2859 | 0.2859 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 0.3601 | 0.3601 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.041 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.041 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0192 | 0.3601 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0069 | 0 | 0.5 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 0.3601 | 0.3601 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.52 uM | Inhibition of Nicotiana tabacum (tobacco) recombinant PPO assessed as protoporphyrinogen IX formation at room temperature by fluorimetric assay | ChEMBL. | 23623257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.