Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Gamma-amino-N-butyrate transaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes similar to S. cerevisiae UGA1 (YGR019W) gamma-aminobutyrate (GABA) transaminase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Candida albicans | one of two potential aminotransferase genes | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Mycobacterium ulcerans | L-lysine aminotransferase | Get druggable targets OG5_129508 | All targets in OG5_129508 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0177 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0106 | 0.0145 | 0.0145 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0332 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0177 | 0.3217 | 0.3117 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0293 | 0.829 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0332 | 1 | 1 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0293 | 0.829 | 0.8265 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0106 | 0.0145 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0332 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0178 | 0.3299 | 0.3299 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0178 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0177 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.3299 | 0.32 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0293 | 0.829 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0178 | 0.3299 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0178 | 0.3299 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.56 uM | Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NADPH generation after 30 min by spectrophotometric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.