Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0184 | 0.1912 | 0.1843 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0514 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0343 | 0.5795 | 0.5759 |
Schistosoma mansoni | tyrosine kinase | 0.0343 | 0.5795 | 0.5759 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0343 | 0.5795 | 0.5759 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0514 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0514 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0109 | 0.0084 | 0.0084 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0343 | 0.5795 | 0.5795 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0514 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0514 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0184 | 0.1912 | 0.1912 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0514 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0184 | 0.1912 | 0.1843 |
Schistosoma mansoni | tyrosine kinase | 0.0182 | 0.1864 | 0.1795 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0184 | 0.1912 | 0.1843 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0343 | 0.5795 | 0.5759 |
Schistosoma mansoni | tyrosine kinase | 0.0182 | 0.1864 | 0.1795 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0514 | 1 | 1 |
Leishmania major | 0.0514 | 1 | 0.5 | |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0184 | 0.1912 | 0.1843 |
Echinococcus multilocularis | insulin receptor | 0.0109 | 0.0084 | 0.0084 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0514 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0182 | 0.1864 | 0.1795 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (ADMET) | = 0.313 g/acre | Toxicity in two leaf stage of Oryza sativa var. Nihonbare (rice) assessed as dose required to selectivity to Oryza sativa | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.