Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ABC transporter | 0.0007 | 0.0006 | 0.0006 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0064 | 0.3446 | 0.339 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0009 | 0.0085 | 0.5 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0009 | 0.0085 | 0.5 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0064 | 0.3446 | 0.339 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0173 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0064 | 0.3446 | 0.339 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0173 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0009 | 0.0085 | 0.5 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.0009 | 0.0085 | 0.5 |
Giardia lamblia | ABC transporter | 0.0009 | 0.0079 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0173 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0173 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0009 | 0.0085 | 0.0085 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.0009 | 0.0085 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.0009 | 0.0085 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0064 | 0.3446 | 0.339 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0173 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0173 | 1 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0064 | 0.3446 | 0.339 |
Leishmania major | 0.0173 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.