Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | WD40 repeat protein | 0.0638 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.0638 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.195 | 0.157 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0638 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.0451 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.195 | 0.157 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.195 | 0.195 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.195 | 0.195 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.5 |
Echinococcus multilocularis | protein will die slowly | 0.0638 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0451 | 0.0451 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0451 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0267 | 0.0267 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.195 | 0.157 |
Onchocerca volvulus | 0.0638 | 1 | 0.5 | |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.195 | 0.195 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0267 | 0.0267 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0638 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0267 | 0.0267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | = 300 mg kg-1 | Antiepileptic activity in Mus musculus (mouse) assessed as minimum dose required to protect half or more number of animals against maximal electroshock-induced seizures after 0.5 hr | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.