Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Spodoptera littoralis | Ecdysone receptor | Starlite/ChEMBL | References |
Bombyx mori | Ecdysone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Ecdysone receptor | 585 aa | 476 aa | 25.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | enteropeptidase | 0.0268 | 0.6588 | 1 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0268 | 0.6588 | 1 |
Brugia malayi | Trypsin family protein | 0.0268 | 0.6588 | 0.6588 |
Brugia malayi | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Echinococcus multilocularis | Mastin | 0.0268 | 0.6588 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0268 | 0.6588 | 1 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Brugia malayi | Trypsin family protein | 0.0268 | 0.6588 | 0.6588 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0268 | 0.6588 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0268 | 0.6588 | 0.6588 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.6588 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0268 | 0.6588 | 1 |
Echinococcus granulosus | Mastin | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Brugia malayi | Trypsin family protein | 0.0268 | 0.6588 | 0.6588 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0395 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.6588 | 0.6588 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0268 | 0.6588 | 0.6588 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0268 | 0.6588 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0268 | 0.6588 | 0.6588 |
Onchocerca volvulus | 0.0268 | 0.6588 | 0.6588 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Brugia malayi | Trypsin family protein | 0.0268 | 0.6588 | 0.6588 |
Echinococcus granulosus | enteropeptidase | 0.0268 | 0.6588 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0268 | 0.6588 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.17 | Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20069627 |
EC50 (binding) | = 7.48 | Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay | ChEMBL. | 20069627 |
Efficacy (binding) | = 95 % | Agonist activity at ecdysone receptor in Bombyx mori Bm5 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide | ChEMBL. | 20069627 |
Efficacy (binding) | = 114 % | Agonist activity at ecdysone receptor in Spodoptera littoralis Sl2 cells after 24 hr by luciferase reporter gene assay relative to tebufenozide | ChEMBL. | 20069627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.