Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.1214 | 0.3757 | 1 |
Leishmania major | protein kinase, putative | 0.0019 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.3199 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0019 | 0 | 0.5 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.1214 | 0.3757 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1214 | 0.3757 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1214 | 0.3757 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3199 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli at 10 mg/ml after 24 hrs by disc diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antibacterial activity against Escherichia coli at 6.25 to 200 ug/ml after 24 hrs by microwell dilution method | ChEMBL. | No reference | |
Activity (functional) | Antifungal activity against Candida albicans at 10 mg/ml after 48 hrs by disc diffusion method | ChEMBL. | No reference | |
Activity (functional) | = 57.41 % | Cytotoxicity against human T47D assessed as cell growth at 10 uM after 48 hrs by SRB assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.