Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0055 | 0.3472 | 0.3725 | |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0472 | 0.0479 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.2939 | 0.2981 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.014 | 0.9321 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.5038 | 0.511 |
Echinococcus multilocularis | 0.0045 | 0.2779 | 0.2819 | |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0009 | 0.0266 | 0.0269 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0472 | 0.0479 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.5153 | 0.5227 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0009 | 0.0266 | 0.0266 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0009 | 0.0266 | 0.0269 |
Echinococcus multilocularis | neuroglian | 0.0011 | 0.0428 | 0.0434 |
Echinococcus multilocularis | insulin receptor | 0.0048 | 0.2939 | 0.2981 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0635 | 0.0644 |
Echinococcus granulosus | Immunoglobulin | 0.0009 | 0.0266 | 0.0269 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.5153 | 0.5227 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0635 | 0.0635 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Brugia malayi | Protein kinase domain containing protein | 0.0048 | 0.2939 | 0.2939 |
Echinococcus granulosus | peroxidasin | 0.0006 | 0.0045 | 0.0046 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.986 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0009 | 0.0266 | 0.0266 |
Schistosoma mansoni | nephrin | 0.0011 | 0.0428 | 0.0434 |
Schistosoma mansoni | tyrosine kinase | 0.0048 | 0.2939 | 0.2981 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.5153 | 0.5227 |
Echinococcus granulosus | defective proboscis extension response | 0.0009 | 0.0266 | 0.0269 |
Schistosoma mansoni | vesicular amine transporter | 0.0009 | 0.0266 | 0.0269 |
Echinococcus granulosus | neuroglian | 0.0011 | 0.0428 | 0.0434 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0048 | 0.2939 | 0.2939 |
Brugia malayi | Peroxidasin | 0.0006 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0472 | 0.0472 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.015 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0311 | 0.0311 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.986 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0009 | 0.0266 | 0.0269 |
Echinococcus granulosus | insulin receptor | 0.0048 | 0.2939 | 0.2981 |
Echinococcus granulosus | twitchin | 0.0011 | 0.0428 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0048 | 0.2939 | 0.2981 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0635 | 0.0644 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0266 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0048 | 0.2939 | 0.2981 |
Onchocerca volvulus | 0.0136 | 0.9043 | 0.9702 | |
Schistosoma mansoni | tyrosine kinase | 0.0007 | 0.0115 | 0.0117 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.986 | 0.986 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.986 | 0.986 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.986 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.5153 | 0.5227 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0266 | 0.0266 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.5038 | 0.511 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.5153 | 0.5227 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.5038 | 0.511 |
Echinococcus multilocularis | peroxidasin | 0.0006 | 0.0045 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0635 | 0.0635 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0266 | 0.0269 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antifungal activity against Candida albicans NCIM 3471 at 1000 ug/disk after 72 hr by disk diffusion method | ChEMBL. | No reference | |
DIZ (functional) | Antifungal activity against Candida albicans NCIM 3471 at 500 ug/disk after 72 hr by disk diffusion method | ChEMBL. | No reference | |
IZ (functional) | = 9 mm | Antibacterial activity against Escherichia coli NCIM 2065 at 500 ug/disk after 24 hr by disk diffusion method | ChEMBL. | No reference |
IZ (functional) | = 11 mm | Antibacterial activity against Escherichia coli NCIM 2065 at 1000 ug/disk after 24 hr by disk diffusion method | ChEMBL. | No reference |
MIC (functional) | Antifungal activity against Candida albicans NCIM 3471 after 72 hr by broth dilution assay | ChEMBL. | No reference | |
MIC (functional) | = 31.2 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2065 after 24 hr by broth dilution assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.