Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.1267 | 0.6217 | 0.5936 |
Schistosoma mansoni | tyrosine kinase | 0.0931 | 0.3592 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0931 | 0.3592 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0559 | 0.0691 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0941 | 0.367 | 0.32 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1267 | 0.6217 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1751 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0941 | 0.367 | 0.32 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.1267 | 0.6217 | 0.5936 |
Schistosoma mansoni | tyrosine kinase | 0.0931 | 0.3592 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.1267 | 0.6217 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.1267 | 0.6217 | 0.5936 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0941 | 0.367 | 0.3299 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.1267 | 0.6217 | 0.5995 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1267 | 0.6217 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1751 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0559 | 0.0691 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1751 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1751 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.1267 | 0.6217 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.1267 | 0.6217 | 0.5936 |
Schistosoma mansoni | tyrosine kinase | 0.0941 | 0.367 | 0.32 |
Leishmania major | 0.1267 | 0.6217 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0941 | 0.367 | 0.32 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 18 mm | Antimicrobial activity against Escherichia coli at 200 ug/ml after 48 hr by cup-plate method | ChEMBL. | No reference |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Escherichia coli after overnight incubation by broth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.