Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin receptor | 0.0108 | 0.0056 | 0.0056 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0337 | 0.3836 | 0.3802 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.071 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.1265 | 0.1217 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.071 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.071 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0335 | 0.3809 | 0.3809 |
Brugia malayi | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | steroid hormone receptor | 0.071 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0335 | 0.3809 | 0.3809 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | conserved hypotetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0337 | 0.3836 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.071 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0337 | 0.3836 | 0.3802 |
Brugia malayi | nuclear receptor NHR-88 | 0.071 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.071 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | nuclear receptor RXR | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.071 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0375 | 0.4472 | 0.4441 |
Onchocerca volvulus | 0.071 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0335 | 0.3809 | 0.3809 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0375 | 0.4472 | 0.4472 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.071 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.071 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Brugia malayi | tailless protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0108 | 0.0056 | 0.0056 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.071 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0179 | 0.1234 | 0.1185 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.1265 | 0.1217 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.071 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | nuclear hormone receptor | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.071 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0181 | 0.1265 | 0.1217 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | zinc finger protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | nuclear receptor NHR-67 | 0.0335 | 0.3809 | 0.3774 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.071 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.071 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.071 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.071 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.071 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0335 | 0.3809 | 0.3809 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.071 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.071 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0179 | 0.1234 | 0.1185 |
Schistosoma mansoni | tyrosine kinase | 0.0179 | 0.1234 | 0.1185 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.071 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0337 | 0.3836 | 0.3802 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.071 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.071 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.071 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | FTZ F1 alpha | 0.071 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0181 | 0.1265 | 0.1217 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.071 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.071 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.071 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.071 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0181 | 0.1265 | 0.1265 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.071 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.071 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0335 | 0.3809 | 0.3809 |
Echinococcus multilocularis | FTZ F1 alpha | 0.071 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Schistosoma mansoni | nuclear receptor | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.071 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.071 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | nuclear hormone receptor | 0.0335 | 0.3809 | 0.3774 |
Brugia malayi | nuclear hormone receptor | 0.071 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.071 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0337 | 0.3836 | 0.3802 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.071 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0335 | 0.3809 | 0.3774 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0375 | 0.4472 | 0.4441 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0335 | 0.3809 | 0.3774 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0335 | 0.3809 | 0.3809 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0335 | 0.3809 | 0.3774 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.071 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.071 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4472 | 0.4441 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.071 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.