Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0405 | 0 | 0.5 |
Plasmodium falciparum | potassium channel | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0405 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0405 | 0 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0405 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0405 | 0 | 0.5 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.6731 | 1 | 1 |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Schistosoma mansoni | twik family of potassium channels-related | 0.6731 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0405 | 0 | 0.5 |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Toxoplasma gondii | ion channel protein | 0.0405 | 0 | 0.5 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.6731 | 1 | 1 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0405 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0405 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0405 | 0 | 0.5 |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.6731 | 1 | 1 |
Plasmodium vivax | potassium channel, putative | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0405 | 0 | 0.5 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0405 | 0 | 0.5 |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0405 | 0 | 0.5 |
Plasmodium falciparum | potassium channel | 0.0405 | 0 | 0.5 |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Onchocerca volvulus | 0.0405 | 0 | 0.5 | |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0405 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0405 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6731 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6326 | 0.936 | 0.936 |
Plasmodium vivax | potassium channel, putative | 0.0405 | 0 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.0405 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0405 | 0 | 0.5 |
Mycobacterium ulcerans | ion transport protein | 0.0405 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0405 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0405 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0405 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0405 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Microbiostatic activity against Candida albicans ATCC 76615 | ChEMBL. | No reference | |
Activity (functional) | Microbiostatic activity against Escherichia coli ATCC 25922 after 48 hr | ChEMBL. | No reference | |
MIC (functional) | = 32 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hr by two-fold serial dilution method | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 76615 after 48 hr by two-fold serial dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.