Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protoporphyrinogen oxidase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0646 | 0.0646 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.226 | 0.226 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0646 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.009 | 0.4289 | 0.4203 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Echinococcus granulosus | epidermal growth factor receptor | 0.009 | 0.4289 | 0.4987 |
Echinococcus granulosus | insulin receptor | 0.0054 | 0.226 | 0.2627 |
Schistosoma mansoni | tyrosine kinase | 0.0167 | 0.8601 | 0.8601 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0646 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0158 | 0.8107 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0054 | 0.226 | 0.2143 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0054 | 0.226 | 0.2143 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0167 | 0.8583 | 0.9979 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.4289 | 0.4289 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0646 | 0.5 |
Echinococcus multilocularis | 0.0051 | 0.2114 | 0.1995 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0148 | 0.017 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0167 | 0.8601 | 0.9841 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0169 | 0.873 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0167 | 0.8601 | 0.9853 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0646 | 0.074 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0192 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0646 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0.0646 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0054 | 0.226 | 0.1996 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.4289 | 0.4289 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0646 | 0.0751 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0167 | 0.8601 | 1 |
Onchocerca volvulus | 0.0154 | 0.7853 | 0.9659 | |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.8583 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0.0646 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.009 | 0.4289 | 0.4987 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0025 | 0.0646 | 0.0505 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.4183 | 0.4183 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0025 | 0.0646 | 0.0646 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0167 | 0.8601 | 0.858 |
Echinococcus multilocularis | 0.0025 | 0.0646 | 0.0505 | |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0169 | 0.873 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0.0646 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.4183 | 0.4183 |
Schistosoma mansoni | tyrosine kinase | 0.0088 | 0.4183 | 0.4183 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0054 | 0.226 | 0.2589 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0.0646 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0025 | 0.0646 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0025 | 0.0646 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0.0646 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0.0646 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0054 | 0.226 | 0.2627 |
Schistosoma mansoni | tyrosine kinase | 0.0054 | 0.226 | 0.226 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0.0646 | 0.0751 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0148 | 0.017 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0148 | 0.0173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.