Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase subunit beta | 0.0119 | 0.1437 | 0.1838 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0119 | 0.1437 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0251 | 0.4842 | 0.6192 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0251 | 0.4842 | 0.6192 |
Echinococcus multilocularis | AMPK beta subunit | 0.0119 | 0.1437 | 0.1838 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0336 | 0.7053 | 0.9019 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0365 | 0.782 | 1 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0365 | 0.782 | 1 |
Brugia malayi | loechrig isoform VII | 0.0365 | 0.782 | 0.7454 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0119 | 0.1437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.9691 | 0.964 |
Onchocerca volvulus | Alicorn homolog | 0.0104 | 0.1045 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0119 | 0.1437 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0365 | 0.782 | 0.7454 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0251 | 0.4842 | 0.3976 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0119 | 0.1437 | 0.5 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0251 | 0.4842 | 0.3976 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0071 | 0.0166 | 0.5 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0251 | 0.4842 | 0.6192 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0365 | 0.782 | 1 |
Echinococcus granulosus | AMPK beta subunit | 0.0119 | 0.1437 | 0.1838 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0365 | 0.782 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0.85 % | Inhibition of glutathione S-transferase P1-1 in Homo sapiens (human) HL60 cell lysate using CDNB and GSH as substrate at 20 uM by spectrophotometric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.