Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | RUN | 0.0147 | 0.1742 | 0.1742 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0147 | 0.1742 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0815 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0035 | 0.0353 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0039 | 0.0403 | 0.2312 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1742 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0147 | 0.1742 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0039 | 0.0403 | 0.0403 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0039 | 0.0403 | 0.2312 |
Schistosoma mansoni | polycystin 1-related | 0.0147 | 0.1742 | 0.1742 |
Echinococcus multilocularis | RUN | 0.0147 | 0.1742 | 0.1742 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0039 | 0.0403 | 0.0403 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0039 | 0.0403 | 1 |
Echinococcus multilocularis | macrophage expressed protein | 0.0587 | 0.7177 | 0.7177 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0147 | 0.1742 | 0.1742 |
Loa Loa (eye worm) | doublecortin family protein | 0.0147 | 0.1742 | 1 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0065 | 0.0727 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0147 | 0.1742 | 0.1742 |
Schistosoma mansoni | rab6-interacting | 0.0147 | 0.1742 | 0.1742 |
Brugia malayi | Doublecortin family protein | 0.0147 | 0.1742 | 1 |
Echinococcus granulosus | macrophage expressed protein | 0.0587 | 0.7177 | 0.7177 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0403 | 0.2312 |
Trypanosoma brucei | prolyl endopeptidase | 0.0039 | 0.0403 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0039 | 0.0403 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0039 | 0.0403 | 0.0403 |
Schistosoma mansoni | rab6-interacting | 0.0147 | 0.1742 | 0.1742 |
Schistosoma mansoni | lipoxygenase | 0.0551 | 0.673 | 0.673 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0815 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0147 | 0.1742 | 0.1742 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0015 | 0.0115 | 0.5 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1742 | 1 |
Schistosoma mansoni | loxhd1 | 0.0147 | 0.1742 | 0.1742 |
Onchocerca volvulus | 0.0147 | 0.1742 | 1 | |
Chlamydia trachomatis | hypothetical protein | 0.0065 | 0.0727 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1742 | 1 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0065 | 0.0727 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0587 | 0.7177 | 0.7177 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0147 | 0.1742 | 0.1742 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0147 | 0.1742 | 0.1742 |
Onchocerca volvulus | 0.0147 | 0.1742 | 1 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0147 | 0.1742 | 0.1742 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.1742 | 0.1742 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0039 | 0.0403 | 0.0403 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0015 | 0.0115 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.943 uM | Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor | ChEMBL. | 15149682 |
IA (functional) | = 3 | Intrinsic activity (IA) at human Beta-1 adrenergic receptor (at 30uM, represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 4 | Intrinsic activity (IA) human Beta-2 adrenergic receptor (at 30uM, represent by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 96 | Intrinsic activity (IA) at human Beta-3 adrenergic receptor (represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.