Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0242 | 0.0242 |
Trypanosoma brucei | prolyl endopeptidase | 0.0047 | 0.0376 | 0.0826 |
Brugia malayi | Doublecortin family protein | 0.0142 | 0.1515 | 0.3654 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0242 | 0.0583 |
Schistosoma mansoni | hypothetical protein | 0.0714 | 0.837 | 0.837 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0079 | 0.0759 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.055 | 0.055 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.0929 | 0.0929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0345 | 0.0345 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0345 | 0.0345 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0576 | 0.0576 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0345 | 0.0345 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0047 | 0.0376 | 0.0826 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0218 | 0.0525 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.0967 | 0.0967 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.0929 | 0.0929 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.055 | 0.055 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0142 | 0.1515 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0345 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.2028 | 0.489 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.0576 | 0.0576 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0345 | 0.0831 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0345 | 0.0345 |
Brugia malayi | hypothetical protein | 0.0142 | 0.1515 | 0.3654 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.0967 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1515 | 0.3654 |
Echinococcus multilocularis | macrophage expressed protein | 0.0714 | 0.837 | 0.837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.055 | 0.055 |
Onchocerca volvulus | 0.0142 | 0.1515 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0345 | 0.0345 |
Schistosoma mansoni | polycystin 1-related | 0.0142 | 0.1515 | 0.1515 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1515 | 0.3654 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0345 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0242 | 0.0583 |
Schistosoma mansoni | lipoxygenase | 0.0595 | 0.6934 | 0.6934 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.055 | 0.1325 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.055 | 0.055 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0047 | 0.0376 | 0.0907 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0242 | 0.0242 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0019 | 0.0037 | 0.5 |
Onchocerca volvulus | 0.0142 | 0.1515 | 1 | |
Schistosoma mansoni | rab6-interacting | 0.0142 | 0.1515 | 0.1515 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0576 | 0.0576 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0142 | 0.1515 | 0.1515 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0047 | 0.0376 | 0.0376 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.055 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0967 | 0.2331 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0142 | 0.1515 | 0.1515 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0203 | 0.049 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.0576 | 0.0576 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0047 | 0.0376 | 0.0826 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.055 | 0.1325 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0345 | 0.0345 |
Echinococcus multilocularis | RUN | 0.0142 | 0.1515 | 0.1515 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0142 | 0.1515 | 0.1515 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0142 | 0.1515 | 0.1515 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.0967 | 0.0967 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0218 | 0.0218 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0142 | 0.1515 | 0.1515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.055 | 0.055 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.055 | 0.1325 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.4148 | 1 |
Brugia malayi | hypothetical protein | 0.0142 | 0.1515 | 0.3654 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.055 | 0.055 |
Schistosoma mansoni | lipoxygenase | 0.085 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0576 | 0.0576 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0142 | 0.1515 | 0.1515 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0405 | 0.0977 |
Schistosoma mansoni | rab6-interacting | 0.0142 | 0.1515 | 0.1515 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0405 | 0.0977 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0405 | 0.0977 |
Chlamydia trachomatis | hypothetical protein | 0.0079 | 0.0759 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0047 | 0.0376 | 0.0376 |
Loa Loa (eye worm) | doublecortin family protein | 0.0142 | 0.1515 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0376 | 0.0907 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.055 | 0.1325 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0405 | 0.0977 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0362 | 0.4148 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.055 | 0.1325 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0047 | 0.0376 | 0.0376 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.085 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.0967 | 0.0967 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0047 | 0.0376 | 0.0376 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0019 | 0.0037 | 0.5 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0079 | 0.0759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0538 | 0.1296 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0042 | 0.0317 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.1515 | 0.1515 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0362 | 0.4148 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.0576 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0218 | 0.0525 |
Schistosoma mansoni | loxhd1 | 0.0142 | 0.1515 | 0.1515 |
Echinococcus granulosus | RUN | 0.0142 | 0.1515 | 0.1515 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0142 | 0.1515 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.055 | 0.1325 |
Echinococcus granulosus | macrophage expressed protein | 0.0714 | 0.837 | 0.837 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0362 | 0.4148 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0362 | 0.4148 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.265 uM | Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor | ChEMBL. | 15149682 |
IA (functional) | = 6 | Intrinsic activity (IA) at human Beta-1 adrenergic receptor (at 30uM, represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 11 | Intrinsic activity (IA) human Beta-2 adrenergic receptor (at 30uM, represent by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 84 | Intrinsic activity (IA) at human Beta-3 adrenergic receptor (represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.