Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.1081 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0198 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.1081 | 1 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.1081 | 1 | 1 |
Treponema pallidum | licC protein (licC) | 0.0198 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 40.49 % | Analgesic activity in Mus musculus NMRI (mouse) assessed as inhibition of early phase of formalin-induced nociception at 30 umol/kg, ip administered 30 min before formalin injection relative to control | ChEMBL. | No reference |
Inhibition (functional) | = 68.27 % | Analgesic activity in Mus musculus NMRI (mouse) assessed as inhibition of late phase of formalin-induced nociception at 30 umol/kg, ip administered 30 min before formalin injection relative to control | ChEMBL. | No reference |
Ratio (functional) | = 0.91 | Analgesic activity in Mus musculus NMRI (mouse) assessed as inhibition of late phase of formalin-induced nociception at 30 umol/kg, ip administered 30 min before formalin injection relative to mefenamic acid | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.