Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0927 | 0.5693 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0927 | 0.5693 | 0.5682 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1545 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1545 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.1735 | 0.3017 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0927 | 0.5693 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1545 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 0.1735 | 0.3048 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.0572 | 0.0966 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0927 | 0.5693 | 0.5682 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.0572 | 0.1005 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0927 | 0.5693 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0572 | 0.0966 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.036 | 0.1735 | 0.1714 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 0.1735 | 0.3017 |
Loa Loa (eye worm) | hypothetical protein | 0.1545 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0558 | 0.094 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0558 | 0.094 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0558 | 0.094 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0927 | 0.5693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0789 | 0.4731 | 0.4717 |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0025 | 0.0044 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.036 | 0.1735 | 0.1714 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0025 | 0.0044 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.0572 | 0.0966 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0572 | 0.0966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.75 | Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA | ChEMBL. | 17689836 |
IC50 (functional) | = 0.55 uM | Concentration needed to inhibit 50% growth of human SKBr3 (breast carcinoma) cell lines | ChEMBL. | 10966743 |
IC50 (functional) | = 0.55 uM | Concentration needed to inhibit 50% growth of human SKBr3 (breast carcinoma) cell lines | ChEMBL. | 10966743 |
IC50 (functional) | = 0.75 uM | Concentration needed to inhibit 50% growth of the human A431 (epidermoid carcinoma) cell lines | ChEMBL. | 10966743 |
IC50 (functional) | = 0.75 uM | Concentration needed to inhibit 50% growth of the human A431 (epidermoid carcinoma) cell lines | ChEMBL. | 10966743 |
IC50 (binding) | = 1.79 uM | Concentration needed to inhibit the autophosphorylation of the cytoplasmic domain of Epidermal growth factor receptor using DELFIA/time-resolved fluorometry. | ChEMBL. | 10966743 |
IC50 (binding) | = 1.79 uM | Concentration needed to inhibit the autophosphorylation of the cytoplasmic domain of Epidermal growth factor receptor using DELFIA/time-resolved fluorometry. | ChEMBL. | 10966743 |
IC50 (functional) | = 2.89 uM | Concentration needed to inhibit 50% growth of human SW620 (colon carcinoma) cell lines | ChEMBL. | 10966743 |
IC50 (functional) | = 2.89 uM | Concentration needed to inhibit 50% growth of human SW620 (colon carcinoma) cell lines | ChEMBL. | 10966743 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10966743 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.