Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bifunctional protein NCOAT | 0.2607 | 1 | 0.5 |
Schistosoma mansoni | Hyaluronidase | 0.2607 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.2607 | 1 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.2607 | 1 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.2607 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hr by two-fold microdilution technique | ChEMBL. | No reference |
MIC (functional) | = 64 ug ml-1 | Microbiostatic activity against Candida albicans ATCC 76615 after 48 hr by two-fold microdilution technique | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | Microbiostatic activity against Saccharomyces cerevisiae ATCC 74212 after 48 hr by two fold microdilution technique | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.