Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0471 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0471 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Plasmodium falciparum | potassium channel | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Trypanosoma cruzi | ion transport protein, putative | 0.0471 | 0 | 0.5 |
Leishmania major | ion transport protein-like protein | 0.0471 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0471 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0471 | 0 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0471 | 0 | 0.5 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.7825 | 1 | 1 |
Plasmodium falciparum | potassium channel | 0.0471 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0471 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0471 | 0 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.7825 | 1 | 1 |
Plasmodium vivax | potassium channel, putative | 0.0471 | 0 | 0.5 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0471 | 0 | 0.5 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0471 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0471 | 0 | 0.5 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.7825 | 1 | 1 |
Toxoplasma gondii | ion channel protein | 0.0471 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0471 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0471 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0471 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0471 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0471 | 0 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.7825 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0471 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.7825 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7354 | 0.936 | 0.936 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Mycobacterium ulcerans | ion transport protein | 0.0471 | 0 | 0.5 |
Onchocerca volvulus | 0.0471 | 0 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0471 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0471 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 43.55 uM | Cytotoxicity against Homo sapiens (human) K562 cells after 24 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.