Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GCC2 and GCC3 family protein | 0.0169 | 0.0113 | 0.0308 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1802 | 0.1802 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Loa Loa (eye worm) | hypothetical protein | 0.1701 | 0.7663 | 0.7663 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0169 | 0.0113 | 0.0308 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Plasmodium vivax | cysteine repeat modular protein 3, putative | 0.0169 | 0.0113 | 0.5 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.1887 | 0.8583 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0169 | 0.0113 | 0.5 |
Onchocerca volvulus | 0.0511 | 0.1802 | 0.2237 | |
Giardia lamblia | CEGP1 protein | 0.0169 | 0.0113 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 2 | 0.0169 | 0.0113 | 0.5 |
Echinococcus granulosus | endonuclease reverse transcriptase | 0.0169 | 0.0113 | 0.0132 |
Onchocerca volvulus | 0.0381 | 0.1158 | 0.1384 | |
Schistosoma mansoni | ephrin receptor | 0.1719 | 0.7753 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0387 | 0.119 | 0.3237 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0511 | 0.1802 | 0.1802 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0387 | 0.119 | 0.1387 |
Onchocerca volvulus | 0.1701 | 0.7663 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.1158 | 0.1158 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0387 | 0.119 | 0.1387 |
Plasmodium falciparum | cysteine repeat modular protein 3 | 0.0169 | 0.0113 | 0.5 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Brugia malayi | hypothetical protein | 0.0511 | 0.1802 | 0.49 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0892 | 0.3677 | 0.3677 |
Brugia malayi | hypothetical protein | 0.0381 | 0.1158 | 0.3149 |
Entamoeba histolytica | protein kinase, putative | 0.0169 | 0.0113 | 0.5 |
Brugia malayi | ephrin receptor 1 precursor | 0.0853 | 0.3486 | 0.9481 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0113 | 0.0113 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0511 | 0.1802 | 0.49 |
Entamoeba histolytica | cysteine-rich surface protein, putative | 0.0169 | 0.0113 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0169 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1802 | 0.1802 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Echinococcus multilocularis | endonuclease reverse transcriptase | 0.0169 | 0.0113 | 0.0132 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0113 | 0.0113 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0892 | 0.3677 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0169 | 0.0113 | 0.5 |
Toxoplasma gondii | GCC2 and GCC3 domain-containing protein | 0.0169 | 0.0113 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0381 | 0.1158 | 0.5 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0169 | 0.0113 | 0.0308 |
Plasmodium falciparum | conserved protein, unknown function | 0.0169 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 0.3725 | 0.3725 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.1887 | 0.8583 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0387 | 0.119 | 0.1535 |
Toxoplasma gondii | hypothetical protein | 0.0169 | 0.0113 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 4 | 0.0169 | 0.0113 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0511 | 0.1802 | 0.49 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0511 | 0.1802 | 0.1802 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1802 | 0.1802 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0387 | 0.119 | 0.119 |
Plasmodium vivax | hypothetical protein, conserved | 0.0169 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0113 | 0.0113 |
Plasmodium vivax | cysteine repeat modular protein 2, putative | 0.0169 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0892 | 0.3677 | 0.3677 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1802 | 0.1802 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0169 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.1158 | 0.1158 |
Onchocerca volvulus | 0.0892 | 0.3677 | 0.4721 | |
Brugia malayi | LBP/BPI | 0.0381 | 0.1158 | 0.3149 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0169 | 0.0113 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0169 | 0.0113 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0169 | 0.0113 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0511 | 0.1802 | 0.49 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0892 | 0.3677 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0169 | 0.0113 | 0.0308 |
Brugia malayi | hypothetical protein | 0.0511 | 0.1802 | 0.49 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0113 | 0.0146 |
Giardia lamblia | Hypothetical protein | 0.0169 | 0.0113 | 0.5 |
Onchocerca volvulus | 0.0511 | 0.1802 | 0.2237 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0892 | 0.3677 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1802 | 0.1802 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 1000 ug ml-1 | Antimicrobial activity against Escherichia coli 637/2007 by microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.