Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.0359 | 0.782 | 1 |
Echinococcus granulosus | AMPK beta subunit | 0.0117 | 0.1437 | 0.1838 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit gamma | 0.0359 | 0.782 | 1 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0117 | 0.1437 | 0.5 |
Brugia malayi | EST embl|AI107989|AI107989 comes from the 3' UTR, putative | 0.0246 | 0.4842 | 0.3976 |
Echinococcus multilocularis | 5' AMP activated protein kinase catalytic | 0.0246 | 0.4842 | 0.6192 |
Toxoplasma gondii | 5'-AMP-activated protein kinase subunit beta-1 family protein, putative | 0.0069 | 0.0166 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/AMPK protein kinase | 0.0246 | 0.4842 | 0.3976 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.1437 | 0.5 |
Onchocerca volvulus | Alicorn homolog | 0.0103 | 0.1045 | 0.5 |
Loa Loa (eye worm) | loechrig isoform VII | 0.0359 | 0.782 | 0.7454 |
Giardia lamblia | 5-AMP-activated protein kinase, gamma-1 subunit | 0.0359 | 0.782 | 1 |
Schistosoma mansoni | protein kinase subunit gamma | 0.0359 | 0.782 | 1 |
Brugia malayi | loechrig isoform VII | 0.0359 | 0.782 | 0.7454 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0117 | 0.1437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.9691 | 0.964 |
Echinococcus granulosus | 5' AMP activated protein kinase catalytic | 0.0246 | 0.4842 | 0.6192 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0246 | 0.4842 | 0.6192 |
Echinococcus multilocularis | AMPK beta subunit | 0.0117 | 0.1437 | 0.1838 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit gamma | 0.033 | 0.7053 | 0.9019 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0117 | 0.1437 | 0.5 |
Schistosoma mansoni | protein kinase subunit beta | 0.0117 | 0.1437 | 0.1838 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Time (functional) | = 20 s | Antidepressant activity in Mus musculus Kunming (mouse) assessed as decrease in immobility time at 40 mg/kg, po administered 30 min prior to testing measured for 6 min by tail suspension test (Rvb = 110.67 +/- 11.52 secs) | ChEMBL. | No reference |
TIME (functional) | = 65.17 s | Antidepressant activity in Mus musculus Kunming (mouse) assessed as immobility time at 40 mg/kg, po administered 30 min prior to testing measured for 6 min by forced swimming test (Rvb = 177.67 +/- 10.88 secs) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.