Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Protease | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 5 | 0.1847 | 1 | 1 |
Onchocerca volvulus | 0.0471 | 0.2121 | 0.5 | |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1847 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0236 | 0.0771 | 0.0771 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1847 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0207 | 0.0609 | 0.287 |
Brugia malayi | GH02984p | 0.0471 | 0.2121 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0471 | 0.2121 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0174 | 0.0416 | 0.0416 |
Schistosoma mansoni | high-affinity choline transporter | 0.0471 | 0.2121 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.0883 | 0.1814 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.2121 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0471 | 0.2121 | 0.1779 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.8172 | 0.8172 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0471 | 0.2121 | 0.5 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0471 | 0.2121 | 0.1779 |
Schistosoma mansoni | sodium/solute symporter | 0.0471 | 0.2121 | 0.2121 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0278 | 0.1012 | 0.1012 |
Schistosoma mansoni | inositol transporter | 0.1847 | 1 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0471 | 0.2121 | 0.1779 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0471 | 0.2121 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.2121 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1847 | 1 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1847 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.1847 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0255 | 0.0883 | 0.0487 |
Echinococcus multilocularis | solute carrier family 5 | 0.1847 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0255 | 0.0883 | 0.0487 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0188 | 0.0497 | 0.2343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 61 nM | Inhibition of Human immunodeficiency virus 1 protease using Lys-Ala-Arg-Val-Leu-Phe(NO2)-Glu-Ala-Met as substrate | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.