Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0819 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.0166 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0081 | 0.0751 | 0.0751 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0049 | 0.0348 | 0.0348 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0819 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0819 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0348 | 0.0348 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 0.0348 | 0.0348 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0166 | 0.0166 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0819 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0049 | 0.0348 | 0.0348 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0819 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0049 | 0.0348 | 0.0348 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0819 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0819 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0049 | 0.0348 | 0.0348 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0049 | 0.0348 | 0.0348 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0166 | 0.0166 |
Echinococcus granulosus | dna polymerase eta | 0.0049 | 0.0348 | 0.0348 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0819 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0819 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0819 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0819 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0819 | 1 | 1 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0738 | 0.8986 | 0.8986 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0819 | 1 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0819 | 1 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0738 | 0.8986 | 0.8986 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 14 mm | Antibacterial activity against Escherichia coli at 100 ug/disk after 24 hr by paper disk diffusion method | ChEMBL. | No reference |
IZ (functional) | = 19 mm | Antifungal activity against Candida albicans at 100 ug/disk after 48 hr by paper disk diffusion method | ChEMBL. | No reference |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hr by agar streak dilution method | ChEMBL. | No reference |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hr by agar streak dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.