Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.2252 | 0.7353 | 0.7353 |
Trypanosoma brucei | RNA helicase, putative | 0.0814 | 0.0088 | 0.0088 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2252 | 0.7353 | 1 |
Echinococcus granulosus | adenosine kinase | 0.2252 | 0.7353 | 0.5 |
Plasmodium falciparum | aminodeoxychorismate lyase | 0.0797 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.2252 | 0.7353 | 1 |
Leishmania major | adenosine kinase, putative | 0.2252 | 0.7353 | 0.7353 |
Toxoplasma gondii | kinase, pfkB family protein | 0.2252 | 0.7353 | 0.7353 |
Mycobacterium ulcerans | branched-chain amino acid aminotransferase | 0.2776 | 1 | 1 |
Mycobacterium tuberculosis | Branched-chain amino acid transaminase IlvE | 0.2776 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.2252 | 0.7353 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.2252 | 0.7353 | 0.5 |
Entamoeba histolytica | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 0.5 |
Onchocerca volvulus | 0.1996 | 0.6056 | 0.5 | |
Loa Loa (eye worm) | branched-chain amino acid aminotransferase | 0.2776 | 1 | 1 |
Trichomonas vaginalis | subgroup IIIi aminotransferase, putative | 0.2776 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.2252 | 0.7353 | 0.7353 |
Toxoplasma gondii | Branched-chain-amino-acid aminotransferase | 0.2776 | 1 | 1 |
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 1 |
Mycobacterium leprae | PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE | 0.2776 | 1 | 0.5 |
Trichomonas vaginalis | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 0.5 |
Plasmodium vivax | aminodeoxychorismate lyase, putative | 0.0797 | 0 | 0.5 |
Leishmania major | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 1 |
Giardia lamblia | Branched-chain amino acid aminotransferase lateral transfer candidate | 0.2776 | 1 | 1 |
Trypanosoma brucei | branched-chain amino acid aminotransferase, putative | 0.2776 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.2252 | 0.7353 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | % | Agonistic activity determined by ability to stimulate GTP gamma S binding in comparison to nociceptin (N/OFQ); ND = not determined | ChEMBL. | 15454210 |
Activity (binding) | 0 % | Agonistic activity determined by ability to stimulate GTP gamma S binding in comparison to nociceptin (N/OFQ); ND = not determined | ChEMBL. | 15454210 |
Activity (functional) | > 10 % | Partial agonistic activity of the compound was determined by its ability to stimulate NOP in comparison to DAMGO | ChEMBL. | 15454210 |
Activity (functional) | > 10 % | Partial agonistic activity of the compound was determined by its ability to stimulate NOP in comparison to DAMGO | ChEMBL. | 15454210 |
Inhibition (binding) | = 70 % | Inhibitory activity of the compound against human orphanin FQ receptor expressed in recombinant HEK 293 cells | ChEMBL. | 12951102 |
Inhibition (binding) | = 70 % | Inhibitory activity of the compound against human orphanin FQ receptor expressed in recombinant HEK 293 cells | ChEMBL. | 12951102 |
Ki (binding) | = 2.5 nM | Binding affinity for recombinant human mu-opioid receptor was determined by using [3H]- diprenophine radioligand | ChEMBL. | 15454210 |
Ki (binding) | = 2.5 nM | Binding affinity for recombinant human mu-opioid receptor was determined by using [3H]- diprenophine radioligand | ChEMBL. | 15454210 |
Ki (binding) | = 879 nM | Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cells | ChEMBL. | 12951102 |
Ki (binding) | = 879 nM | Binding affinity for opioid receptor like 1 expressed in HEK-293 cells | ChEMBL. | 15454210 |
Ki (binding) | = 879 nM | Binding affinity against human orphanin FQ receptor expressed in recombinant HEK 293 cells | ChEMBL. | 12951102 |
Ki (binding) | = 879 nM | Binding affinity for opioid receptor like 1 expressed in HEK-293 cells | ChEMBL. | 15454210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.