Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.0031 | 0.004 | 0.004 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0066 | 0.0171 | 0.5392 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0048 | 0.0105 | 0.0374 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0046 | 0.0098 | 0.0098 |
Onchocerca volvulus | 0.0048 | 0.0105 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0046 | 0.0098 | 0.1574 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2679 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0038 | 0.0068 | 0.0068 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0071 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1143 | 0.4223 | 0.4223 |
Brugia malayi | intracellular kinase | 0.0048 | 0.0105 | 0.0105 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.2679 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.005 | 0.0114 | 0.0114 |
Schistosoma mansoni | vesicular amine transporter | 0.0046 | 0.0098 | 0.1574 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0066 | 0.0171 | 0.3867 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.2679 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0078 | 0.0219 | 0.0219 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0048 | 0.0105 | 0.1943 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0048 | 0.0105 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.2679 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Schistosoma mansoni | cell adhesion molecule | 0.0046 | 0.0098 | 0.1574 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2679 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0048 | 0.0105 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.005 | 0.0114 | 0.0114 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0096 | 0.0287 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0048 | 0.0105 | 0.0374 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1143 | 0.4223 | 0.4223 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0046 | 0.0098 | 0.1574 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0046 | 0.0098 | 0.0098 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0066 | 0.0171 | 0.3867 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0287 | 0.0287 |
Echinococcus granulosus | twitchin | 0.0047 | 0.01 | 0.0092 |
Loa Loa (eye worm) | glutamate receptor | 0.0078 | 0.0219 | 0.0219 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.2679 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0048 | 0.0105 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0096 | 0.0287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.2679 | 1 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.2679 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0046 | 0.0098 | 0.1574 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0089 | 0.0259 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0048 | 0.0105 | 0.0105 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.2679 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0048 | 0.0105 | 0.0105 |
Echinococcus granulosus | protein kinase shaggy | 0.0048 | 0.0105 | 0.0374 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.2679 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 164.44 uM | Cytotoxicity against Homo sapiens (human) HepG2 cells after 72 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.