Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.2021 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2021 | 0 | 0.5 |
Schistosoma mansoni | serine-type protease inhibitor | 0.207 | 0.0015 | 0.0015 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Leishmania major | ion transport protein-like protein | 0.2021 | 0 | 0.5 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.2021 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2021 | 0 | 0.5 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.2021 | 0 | 0.5 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.2021 | 0 | 0.5 |
Plasmodium vivax | potassium channel, putative | 0.2021 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.2021 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2021 | 0 | 0.5 |
Leishmania major | potassium channel subunit-like protein | 0.2021 | 0 | 0.5 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.2021 | 0 | 0.5 |
Mycobacterium ulcerans | ion transport protein | 0.2021 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Plasmodium falciparum | potassium channel | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.2021 | 0 | 0.5 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.2021 | 0 | 0.5 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 3.3577 | 1 | 1 |
Trypanosoma cruzi | ion transport protein, putative | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Toxoplasma gondii | ion channel protein | 0.2021 | 0 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.2021 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.2021 | 0 | 0.5 |
Plasmodium falciparum | potassium channel | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 3.3577 | 1 | 1 |
Plasmodium vivax | potassium channel, putative | 0.2021 | 0 | 0.5 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 3.3577 | 1 | 1 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.2021 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.2021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 3.3577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 3.1556 | 0.936 | 0.936 |
Schistosoma mansoni | twik family of potassium channels-related | 3.3577 | 1 | 1 |
Schistosoma mansoni | serine-type protease inhibitor | 0.207 | 0.0015 | 0.0015 |
Leishmania major | hypothetical protein, conserved | 0.2021 | 0 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.2021 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2021 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2021 | 0 | 0.5 |
Onchocerca volvulus | 0.2021 | 0 | 0.5 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.2021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5 uM | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 24308997 |
Inhibition (binding) | = 73 % | Inhibition of AKT1 in human PC3 cells using GSK-3beta fusion protein as substrate at 10 nM after 1 hr by Western blotting analysis relative to control | ChEMBL. | 24308997 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24308997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.