Detailed information for compound 1816986

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 832.938 | Formula: C43H56N6O11
  • H donors: 5 H acceptors: 9 LogP: 2.3 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCC(C(=O)C(=O)NCC(=O)N[C@H](C(=O)N(C)C)c1ccccc1)NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@@H](NC(=O)Cc1cccc(OCCCO2)c1)[C@@H]1CC[C@H](CC1)C(=O)O
  • InChi: 1S/C43H56N6O11/c1-4-10-32(38(52)40(54)44-24-35(51)47-36(41(55)48(2)3)27-12-6-5-7-13-27)45-39(53)33-23-31-25-49(33)42(56)37(28-15-17-29(18-16-28)43(57)58)46-34(50)22-26-11-8-14-30(21-26)59-19-9-20-60-31/h5-8,11-14,21,28-29,31-33,36-37H,4,9-10,15-20,22-25H2,1-3H3,(H,44,54)(H,45,53)(H,46,50)(H,47,51)(H,57,58)/t28-,29-,31-,32?,33+,36+,37+/m1/s1
  • InChiKey: DTDQPUBMECMTEJ-JKFVSECISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0843 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0397 0.4525 0.4525
Loa Loa (eye worm) nuclear receptor NHR-67 0.0397 0.4525 0.4525
Brugia malayi nuclear hormone receptor family member nhr-6 0.0397 0.4525 0.4525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0843 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0843 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0767 0.0767
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0397 0.4525 0.4525
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0397 0.4525 0.4525
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.0397 0.4525 0.4525
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0843 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0099 0.0859 0.0859
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0397 0.4525 0.4525
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1352 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0445 0.5112 0.5112
Echinococcus multilocularis ecdysone induced protein 78C 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5112 0.5112
Schistosoma mansoni nuclear receptor 0.0397 0.4525 0.4525
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0843 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0397 0.4525 0.4525
Echinococcus multilocularis caspase 0.0099 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0843 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0843 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0843 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0843 1 1
Onchocerca volvulus 0.0397 0.4525 0.4525
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.1491 0.1491
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0099 0.0859 0.0859
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0099 0.0859 0.0859
Echinococcus granulosus Nuclear hormone receptor HR96 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0843 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0843 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0445 0.5112 0.5112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi hypothetical protein 0.0397 0.4525 0.4525
Schistosoma mansoni nuclear receptor 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0445 0.5112 0.5112
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.1491 0.1491
Brugia malayi conserved hypotetical protein 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0397 0.4525 0.4525
Brugia malayi hypothetical protein 0.0445 0.5112 0.5112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0843 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5112 0.5112
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0843 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0843 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1352 0.5
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1352 1
Brugia malayi tailless protein 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0843 1 1
Echinococcus granulosus caspase 0.0099 0.0859 0.0859
Schistosoma mansoni RAR-like nuclear receptor 0.0843 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0843 1 1
Schistosoma mansoni caspase-3 (C14 family) 0.0099 0.0859 0.0859
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.0767 0.0767
Brugia malayi ecdysone receptor 0.0397 0.4525 0.4525
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0124 0.0124
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0843 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0397 0.4525 0.4525
Echinococcus granulosus ecdysone induced protein 78C 0.0843 1 1
Echinococcus granulosus FTZ F1 alpha 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Brugia malayi hypothetical protein 0.0445 0.5112 0.5112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0843 1 1
Plasmodium vivax RNA helicase-1, putative 0.003 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0397 0.4525 0.4525
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.036 0.036
Loa Loa (eye worm) DR-78 0.0397 0.4525 0.4525
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0843 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0397 0.4525 0.4525
Schistosoma mansoni thyroid hormone receptor 0.0843 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0843 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi nuclear receptor RXR 0.0445 0.5112 0.5112
Schistosoma mansoni nuclear hormone receptor 0.0843 1 1
Brugia malayi nuclear receptor NHR-88 0.0397 0.4525 0.4525
Schistosoma mansoni nuclear hormone receptor 0.0397 0.4525 0.4525
Schistosoma mansoni zinc finger protein 0.0397 0.4525 0.4525
Brugia malayi nuclear receptor RXR 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5112 0.5112
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0767 0.0767
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0843 1 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0124 0.0124
Brugia malayi nuclear hormone receptor family member odr-7 0.0397 0.4525 0.4525
Onchocerca volvulus Protein ultraspiracle homolog 0.0843 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0445 0.5112 0.5112
Loa Loa (eye worm) steroid hormone receptor 0.0843 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0397 0.4525 0.4525
Brugia malayi nuclear receptor NHR-67 0.0397 0.4525 0.4525
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0843 1 1
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0 0.5
Brugia malayi steroid hormone receptor 0.0843 1 1
Brugia malayi jmjC domain containing protein 0.0151 0.1491 0.1491
Schistosoma mansoni jumonji domain containing protein 0.0132 0.1255 0.1255
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.3149 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0843 1 1
Brugia malayi Nuclear hormone receptor E75 0.0397 0.4525 0.4525
Echinococcus multilocularis FTZ F1 alpha 0.0843 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Brugia malayi Steroid receptor seven-up type 2 0.0843 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0843 1 1
Brugia malayi nuclear hormone receptor 0.0843 1 1
Onchocerca volvulus 0.0843 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0397 0.4525 0.4525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0843 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0843 1 1
Brugia malayi nuclear hormone receptor 0.0397 0.4525 0.4525
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.5112 0.5112
Schistosoma mansoni nuclear hormone receptor 0.0397 0.4525 0.4525
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0445 0.5112 0.5112
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0 0.5
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0843 1 1
Schistosoma mansoni coup transcription factor 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0843 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0843 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0397 0.4525 0.4525
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0397 0.4525 0.4525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.3149 1
Onchocerca volvulus 0.0397 0.4525 0.4525
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0092 0.0767 0.0767
Loa Loa (eye worm) nuclear hormone receptor 0.0397 0.4525 0.4525
Brugia malayi hypothetical protein 0.0397 0.4525 0.4525
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0445 0.5112 0.5112
Echinococcus granulosus caspase 3 0.0073 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0843 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0445 0.5112 0.5112
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0445 0.5112 0.5112
Echinococcus multilocularis nuclear receptor nhr 48 0.0397 0.4525 0.4525
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0843 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0843 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0843 1 1
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0397 0.4525 0.4525
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0397 0.4525 0.4525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0767 0.0767
Brugia malayi Nuclear hormone receptor E75 0.0397 0.4525 0.4525
Schistosoma mansoni thyroid hormone receptor 0.0843 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0843 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0397 0.4525 0.4525
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.3149 1
Brugia malayi Nuclear hormone receptor-like 1 0.0843 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.3149 1
Brugia malayi nuclear receptor NHR-88 0.0843 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0843 1 1
Brugia malayi jmjC domain containing protein 0.0092 0.0767 0.0767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0843 1 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.3149 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0426 0.0426
Echinococcus multilocularis caspase 3 0.0073 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0843 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0843 1 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.4525 0.4525

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 19 nM Binding affinity to HCV NS3 protease ChEMBL. 16730985

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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