Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0619 | 0.1212 | 0.0264 |
Schistosoma mansoni | carbonic anhydrase-related | 0.058 | 0.0974 | 0.0974 |
Schistosoma mansoni | carbonic anhydrase-related | 0.058 | 0.0974 | 0.0974 |
Echinococcus granulosus | carbonic anhydrase II | 0.1071 | 0.4 | 0.4 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0919 | 0.3063 | 0.3063 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1071 | 0.4 | 0.336 |
Echinococcus granulosus | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Echinococcus granulosus | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1071 | 0.4 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.058 | 0.0974 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1071 | 0.4 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1071 | 0.4 | 0.3353 |
Echinococcus granulosus | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Echinococcus multilocularis | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Schistosoma mansoni | protein kinase | 0.2045 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1071 | 0.4 | 0.336 |
Schistosoma mansoni | protein kinase | 0.2045 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1071 | 0.4 | 0.4 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1071 | 0.4 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1071 | 0.4 | 0.4 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1071 | 0.4 | 0.3353 |
Schistosoma mansoni | carbonic anhydrase-related | 0.058 | 0.0974 | 0.0974 |
Leishmania major | carbonic anhydrase-like protein | 0.1071 | 0.4 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2042 | 0.9981 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0919 | 0.3063 | 0.3063 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1071 | 0.4 | 0.4 |
Echinococcus multilocularis | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.2045 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.1193 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.058 | 0.0974 | 0.0974 |
Echinococcus multilocularis | carbonic anhydrase | 0.058 | 0.0974 | 0.0974 |
Plasmodium falciparum | carbonic anhydrase | 0.058 | 0.0974 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.2045 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 515 uM | Inhibition constant (Ki) against trypsin enzyme. | ChEMBL. | 10476856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.