Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0178 | 0.7091 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0178 | 0.7091 | 1 |
Giardia lamblia | CDC72 | 0.0178 | 0.7091 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0178 | 0.7091 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0178 | 0.7091 | 1 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0178 | 0.7091 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0178 | 0.7091 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0178 | 0.7091 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0117 | 0.4023 | 0.5673 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0178 | 0.7091 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0178 | 0.7091 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0178 | 0.7091 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0178 | 0.7091 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0178 | 0.7091 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0178 | 0.7091 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0178 | 0.7091 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.