Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.3403 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0058 | 0.0049 | 0.0049 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0413 | 0.0413 |
Mycobacterium tuberculosis | Probable reductase | 0.0123 | 0.0245 | 0.0484 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.0049 | 0.0049 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 1 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.3403 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.0038 | 0.0038 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Echinococcus multilocularis | 0.0056 | 0.0043 | 0.0043 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0049 | 0.0049 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0413 | 0.0413 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0123 | 0.0245 | 0.0484 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 1 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.3403 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0123 | 0.0245 | 0.0484 |
Brugia malayi | hypothetical protein | 0.2648 | 0.7754 | 0.7754 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0137 | 0.0286 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | hypothetical protein | 0.1486 | 0.4297 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0165 | 0.0165 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0123 | 0.0245 | 0.0484 |
Trypanosoma brucei | Prostaglandin E synthase | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0137 | 0.0286 | 0.058 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0165 | 0.0165 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0165 | 0.0165 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Echinococcus multilocularis | 0.3403 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0165 | 0.0165 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0123 | 0.0245 | 0.0484 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.3403 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0413 | 0.0413 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.2648 | 0.7754 | 0.5 | |
Echinococcus granulosus | insulin receptor | 0.0058 | 0.0049 | 0.0049 |
Toxoplasma gondii | prostaglandin-E synthase | 0.2648 | 0.7754 | 0.7746 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0123 | 0.0245 | 0.0484 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0413 | 0.0413 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0137 | 0.0286 | 0.058 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.3403 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0137 | 0.0286 | 0.058 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0162 | 0.0162 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0413 | 0.0376 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.3403 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0049 | 0.0049 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.2648 | 0.7754 | 0.7746 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.3403 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.3403 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1486 | 0.4297 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0058 | 0.0049 | 0.001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Inhibition of partially purified EGFR tyrosine kinase from human A431 cells | ChEMBL. | 17869510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.