TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 217.092 | Formula: C5H9NNaO5P
H donors: 3 H acceptors: 5 LogP: -2.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N(C/C=C/P(=O)(O)[O-])O.[Na+]
InChi: 1S/C5H10NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h2,4,8H,3H2,1H3,(H2,9,10,11);/q;+1/p-1/b4-2+;
InChiKey: FIIFZXQMNAISNE-VEELZWTKSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0212	0.1758
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0212	0.1758
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0212	0.2632
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Schistosoma mansoni	adenoreceptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	opsin-like receptor	0.0014	0.0212	0.1758
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	amine GPCR	0.0014	0.0212	0.1758
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0212	0.3002
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0212	0.3002
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Brugia malayi	AKH receptor	0.0014	0.0212	0.2674
Echinococcus granulosus	sex peptide receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1146	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0503	0.4331
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0212	0.3002
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0212	0.3002
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0212	0.2674
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0212	0.2674
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0212	0.3002
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0212	0.2674
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0212	0.1758
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Brugia malayi	G-protein coupled receptor	0.0014	0.0212	0.2674
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0212	0.2632
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0212	0.1758
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	somatostatin receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0212	0.1758
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0212	0.3002
Brugia malayi	sulfakinin receptor protein	0.0014	0.0212	0.2674
Brugia malayi	GnHR receptor homolog	0.0014	0.0212	0.2674
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0212	0.1758
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0212	0.3002
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0212	0.3002
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0212	0.3002
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Schistosoma mansoni	opsin-like receptor	0.0014	0.0212	0.1758
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0212	0.2632
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.05	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.006	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0212	0.3002
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0212	0.3002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Trichomonas vaginalis	helicase, putative	0.0006	0.006	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus granulosus	serotonin receptor	0.0014	0.0212	0.3002
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.05	1	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0212	0.3002
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	hypothetical protein	0.0014	0.0212	0.1758
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0212	0.2632
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	cpg binding protein	0.003	0.0536	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0212	0.2632
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0212	0.3002
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0212	0.2632
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0108	0.0754
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0212	0.3002
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.05	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0212	0.2674
Brugia malayi	G protein-coupled receptor	0.0014	0.0212	0.2674
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Brugia malayi	RE15519p	0.0014	0.0212	0.2674
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0212	0.2674
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0212	0.3002
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0503	1
Schistosoma mansoni	amine GPCR	0.0014	0.0212	0.1758
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0212	0.2632
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0108	0.0754
Onchocerca volvulus		0.0028	0.0503	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0212	0.1758
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	myosin xvIII	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0212	0.3002
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0212	0.3002
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0212	0.1758
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0503	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0212	0.1758
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0212	0.1758
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0212	0.1758
Echinococcus granulosus	hypothetical protein	0.0014	0.0212	0.3002
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0212	0.3002
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0212	0.3002
Brugia malayi	larval opioid receptor	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0212	0.3002
Schistosoma mansoni	amine GPCR	0.0014	0.0212	0.1758
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0212	0.1758
Echinococcus multilocularis	serotonin receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	cpg binding protein	0.003	0.0536	0.4619
Schistosoma mansoni	amine GPCR	0.0014	0.0212	0.1758
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0212	0.3002
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.05	1	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0212	0.3002
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0212	0.3002
Brugia malayi	putative neuropeptide receptor	0.0014	0.0212	0.2674
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0212	0.1758
Brugia malayi	G-protein coupled receptor	0.0014	0.0212	0.2674
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0073	0.0531
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0212	0.2632
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	hypothetical protein	0.0014	0.0212	0.1758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0212	0.1758
Brugia malayi	Dopamine receptor	0.0014	0.0212	0.2674
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0212	0.3002
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.05	1	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0212	0.3002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0212	0.2674
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Schistosoma mansoni	cpg binding protein	0.003	0.0536	0.4619
Brugia malayi	Serotonin receptor	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	opsin-like receptor	0.0014	0.0212	0.1758
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Brugia malayi	neuropeptide F receptor	0.0014	0.0212	0.2674
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0212	0.3002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0212	0.1758
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0212	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0212	0.3002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0212	0.3002
Echinococcus granulosus	cpg binding protein	0.003	0.0536	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0212	0.2632
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Echinococcus multilocularis	serotonin receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0212	0.3002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0212	0.3002
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0212	0.3002
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0212	0.2674
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0212	0.3002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0212	0.1758
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Brugia malayi	Serotonin receptor	0.0014	0.0212	0.2674
Brugia malayi	neuropeptide F receptor	0.0014	0.0212	0.2674
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0212	0.3002
Schistosoma mansoni	amine GPCR	0.0014	0.0212	0.1758
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0212	0.2674
Schistosoma mansoni	hypothetical protein	0.0014	0.0212	0.1758
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0212	0.2674
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0212	0.2632
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.006	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0212	0.3002
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0212	0.2632
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0212	0.1758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0212	0.1758
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	1
Brugia malayi	hypothetical protein	0.0014	0.0212	0.2674
Schistosoma mansoni	hypothetical protein	0.0014	0.0212	0.1758
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0212	0.3002
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0212	0.2674

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.07 uM	Inhibition of Mycobacterium tuberculosis Dxr	ChEMBL.	24360562
MIC (functional)	= 150 ug ml-1	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition in presence of GAST minimal media	ChEMBL.	24360562
MIC (functional)	> 200 ug ml-1	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition in presence of 7H9 nutrient-rich media	ChEMBL.	24360562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3103256

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1818583