Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.0067 | 0.3286 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0201 | 0.9996 | 0.9994 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0181 | 0.8994 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0201 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0201 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0181 | 0.8994 | 0.8502 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0181 | 0.8994 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0181 | 0.8994 | 0.8502 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0181 | 0.8994 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0181 | 0.8994 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0181 | 0.8994 | 0.8502 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0181 | 0.8994 | 0.8502 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0181 | 0.8994 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0067 | 0.3286 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0201 | 0.9996 | 0.9994 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0181 | 0.8994 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0181 | 0.8994 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0201 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0181 | 0.8994 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0201 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.57 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 24332658 |
Ki (binding) | = 132 nM | Inhibition of human carbonic anhydrase 1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay | ChEMBL. | 24332658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.