TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.375 | Formula: C17H14FN3O3S
H donors: 2 H acceptors: 4 LogP: 2.28 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)CNC(=O)c1sc(nc1C)n1ccc(cc1=O)O
InChi: 1S/C17H14FN3O3S/c1-10-15(16(24)19-9-11-2-4-12(18)5-3-11)25-17(20-10)21-7-6-13(22)8-14(21)23/h2-8,22H,9H2,1H3,(H,19,24)
InChiKey: KHIDEYHOVWAHBR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	stearoyl-Coenzyme A desaturase 1	Starlite/ChEMBL	References
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	fatty acid desaturase, putative	0.0223	1	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	tyrosine kinase	0.0139	0.4481	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0139	0.4481	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0139	0.4481	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0139	0.4481	1
Brugia malayi	Variant SH3 domain containing protein	0.0087	0.1009	0.1146
Brugia malayi	Protein kinase domain containing protein	0.0139	0.4481	0.5089
Loa Loa (eye worm)	hypothetical protein	0.0139	0.4481	0.5089
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0139	0.4481	1
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	tyrosine kinase	0.0139	0.4481	1
Loa Loa (eye worm)	SRC-1	0.0139	0.4481	0.5089
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0139	0.4481	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0139	0.4481	1
Brugia malayi	protein-tyrosine kinase	0.0139	0.4481	0.5089
Echinococcus multilocularis	tyrosine protein kinase shark	0.0139	0.4481	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0139	0.4481	1
Brugia malayi	SH2 domain containing protein	0.0139	0.4481	0.5089
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0139	0.4481	1
Plasmodium falciparum	stearoyl-CoA desaturase	0.0205	0.8804	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0087	0.1009	0.2251
Schistosoma mansoni	hypothetical protein	0.0087	0.1009	0.2251
Schistosoma mansoni	SH2A	0.0087	0.1009	0.2251
Schistosoma mansoni	GTPase activating protein	0.0087	0.1009	0.2251
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0087	0.1009	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0087	0.1009	0.2251
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Schistosoma mansoni	tensin-related	0.0087	0.1009	0.2251
Brugia malayi	Variant SH3 domain containing protein	0.0087	0.1009	0.1146
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Onchocerca volvulus		0.0139	0.4481	0.3861
Schistosoma mansoni	hypothetical protein	0.0087	0.1009	0.2251
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0139	0.4481	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0087	0.1009	0.2251
Brugia malayi	SH2 domain containing protein	0.0139	0.4481	0.5089
Loa Loa (eye worm)	SH2 domain-containing protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	SH2 domain containing protein 7	0.0087	0.1009	0.2251
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0139	0.4481	0.5089
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0087	0.1009	0.2251
Echinococcus granulosus	growth factor receptor bound protein 2	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0087	0.1009	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Echinococcus granulosus	tyrosine kinase	0.0139	0.4481	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0139	0.4481	1
Echinococcus granulosus	hypothetical protein	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0139	0.4481	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Echinococcus multilocularis	SHC transforming protein 3	0.0087	0.1009	0.2251
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Echinococcus granulosus	tyrosine protein kinase Blk	0.0139	0.4481	1
Onchocerca volvulus		0.0223	1	1
Brugia malayi	Protein kinase domain containing protein	0.0139	0.4481	0.5089
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0087	0.1009	0.2251
Echinococcus granulosus	SH2 motif	0.0087	0.1009	0.2251
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0087	0.1009	0.2251
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0205	0.8804	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0087	0.1009	0.2251
Schistosoma mansoni	tensin-related	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0139	0.4481	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0087	0.1009	0.2251
Brugia malayi	Protein kinase domain containing protein	0.0139	0.4481	0.5089
Onchocerca volvulus		0.0223	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0087	0.1009	0.1146
Leishmania major	fatty-acid desaturase, putative	0.0223	1	0.5
Loa Loa (eye worm)	acyl-CoA desaturase	0.0205	0.8804	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	expressed conserved protein	0.0087	0.1009	0.2251
Schistosoma mansoni	growth factor receptor-bound protein	0.0087	0.1009	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0139	0.4481	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0087	0.1009	0.2251
Echinococcus granulosus	NCK adaptor protein	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0139	0.4481	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0087	0.1009	0.1146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0139	0.4481	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0139	0.4481	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0139	0.4481	1
Echinococcus multilocularis	SH2 motif	0.0087	0.1009	0.2251
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0139	0.4481	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0087	0.1009	0.1146
Schistosoma mansoni	signal transduction protein lnk-related	0.0087	0.1009	0.2251
Schistosoma mansoni	nck2/grb4	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0139	0.4481	1
Echinococcus granulosus	c src tyrosine kinase	0.0139	0.4481	1
Echinococcus multilocularis	SH2 motif	0.0087	0.1009	0.2251
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Brugia malayi	Tensin	0.0087	0.1009	0.1146
Schistosoma mansoni	tensin	0.0087	0.1009	0.2251
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0139	0.4481	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0139	0.4481	1
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0087	0.1009	0.2251
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0087	0.1009	0.2251
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0087	0.1009	0.1146
Brugia malayi	Variant SH3 domain containing protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	SH2 domain-containing protein	0.0087	0.1009	0.1146
Schistosoma mansoni	suppressor of cytokine signaling	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase shark	0.0139	0.4481	1
Schistosoma mansoni	adapter molecule crk	0.0087	0.1009	0.2251
Schistosoma mansoni	tensin	0.0087	0.1009	0.2251
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0139	0.4481	1
Echinococcus granulosus	N chimaerin	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0139	0.4481	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0139	0.4481	1
Echinococcus multilocularis		0.0087	0.1009	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Onchocerca volvulus		0.0139	0.4481	0.3861
Echinococcus multilocularis	N chimaerin	0.0087	0.1009	0.2251
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0087	0.1009	0.2251
Brugia malayi	SRC-1	0.0139	0.4481	0.5089
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0087	0.1009	0.2251
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine protein kinase Srms	0.0139	0.4481	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0139	0.4481	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Onchocerca volvulus		0.0139	0.4481	0.3861
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0139	0.4481	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0087	0.1009	0.1146
Echinococcus granulosus	SH2 motif	0.0087	0.1009	0.2251
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0087	0.1009	0.2251
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0087	0.1009	0.2251
Brugia malayi	RhoGAP domain containing protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	tensin	0.0087	0.1009	0.2251
Echinococcus granulosus	SHC transforming protein 3	0.0087	0.1009	0.2251
Schistosoma mansoni	tensin	0.0087	0.1009	0.2251
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0087	0.1009	0.2251
Onchocerca volvulus		0.0139	0.4481	0.3861
Echinococcus multilocularis	tensin	0.0087	0.1009	0.2251
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0087	0.1009	0.2251
Brugia malayi	Tyrosine-protein kinase abl-1	0.0139	0.4481	0.5089
Echinococcus multilocularis	NCK adaptor protein	0.0087	0.1009	0.2251
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Echinococcus granulosus	tensin	0.0087	0.1009	0.2251
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Schistosoma mansoni	vav2	0.0087	0.1009	0.2251
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Loa Loa (eye worm)	STAT protein	0.0087	0.1009	0.1146
Echinococcus multilocularis	c src tyrosine kinase	0.0139	0.4481	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0087	0.1009	0.2251
Brugia malayi	Sex muscle abnormal protein 5	0.0087	0.1009	0.1146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0139	0.4481	1
Brugia malayi	hypothetical protein	0.0139	0.4481	0.5089
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0087	0.1009	0.2251
Onchocerca volvulus		0.0139	0.4481	0.3861
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0139	0.4481	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0087	0.1009	0.1146
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0139	0.4481	1
Onchocerca volvulus		0.0139	0.4481	0.3861
Brugia malayi	Protein kinase domain containing protein	0.0139	0.4481	0.5089
Brugia malayi	acyl-CoA desaturase	0.0205	0.8804	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0087	0.1009	0.2251
Echinococcus multilocularis	SH2 motif	0.0087	0.1009	0.2251
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0139	0.4481	1
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK protein kinase	0.0139	0.4481	0.5089
Schistosoma mansoni	shc transforming protein	0.0087	0.1009	0.2251
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Brugia malayi	hypothetical protein	0.0087	0.1009	0.1146
Schistosoma mansoni	tyrosine kinase	0.0139	0.4481	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1009	0.1146
Loa Loa (eye worm)	TK/FER protein kinase	0.0139	0.4481	0.5089
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0087	0.1009	0.2251
Brugia malayi	Protein kinase domain containing protein	0.0139	0.4481	0.5089
Brugia malayi	SH2 domain containing protein	0.0087	0.1009	0.1146

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 nM	Inhibition of SCD1 in mouse liver microsomes	ChEMBL.	24370012
IC50 (binding)	= 30 nM	Inhibition of SCD1 in human HepG2 cells using radiolabeled stearic acid as substrate	ChEMBL.	24370012
Inhibition (binding)		Inhibition of human delta-6 desaturase at 10 uM	ChEMBL.	24370012
Inhibition (binding)		Inhibition of human delta-5 desaturase at 10 uM	ChEMBL.	24370012
Papp (ADMET)	= 23 ucm/s	Apparent permeability from basolateral to apical side of human Caco2 cells	ChEMBL.	24370012

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3104405

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1819031