Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.018 | 0.7484 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.018 | 0.7484 | 0.8323 |
Echinococcus multilocularis | pyruvate kinase | 0.0092 | 0.2383 | 0.3184 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.015 | 0.5747 | 0.7679 |
Plasmodium falciparum | pyruvate kinase | 0.018 | 0.7484 | 0.777 |
Loa Loa (eye worm) | pyruvate kinase | 0.018 | 0.7484 | 0.8323 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0.8948 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.018 | 0.7484 | 0.777 |
Echinococcus granulosus | pyruvate kinase | 0.018 | 0.7484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.7484 | 0.8323 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0105 | 0.3122 | 0.3359 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.8948 | 0.5818 |
Echinococcus granulosus | pyruvate kinase | 0.018 | 0.7484 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.018 | 0.7484 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.018 | 0.7484 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.3216 | 0.1633 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.018 | 0.7484 | 0.8332 |
Echinococcus multilocularis | pyruvate kinase | 0.0092 | 0.2383 | 0.3184 |
Onchocerca volvulus | 0.0223 | 1 | 1 | |
Entamoeba histolytica | pyruvate kinase, putative | 0.0125 | 0.4313 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.018 | 0.7484 | 0.8332 |
Giardia lamblia | Pyruvate kinase | 0.018 | 0.7484 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.015 | 0.5747 | 0.6594 |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.4313 | 0.469 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0105 | 0.3122 | 0.1448 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3122 | 0.3325 |
Schistosoma mansoni | pyruvate kinase | 0.018 | 0.7484 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.018 | 0.7484 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.018 | 0.7484 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.2751 | 0.072 |
Echinococcus multilocularis | pyruvate kinase | 0.0142 | 0.5276 | 0.705 |
Echinococcus multilocularis | pyruvate kinase | 0.0092 | 0.2383 | 0.3184 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.018 | 0.7484 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0205 | 0.8948 | 0.5818 |
Echinococcus multilocularis | pyruvate kinase | 0.018 | 0.7484 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0125 | 0.4313 | 0.469 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.2751 | 0.3675 |
Loa Loa (eye worm) | pyruvate kinase | 0.018 | 0.7484 | 0.8323 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0.8948 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.018 | 0.7484 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.018 | 0.7484 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.018 | 0.7484 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0105 | 0.3122 | 0.4171 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0.8948 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0.8948 | 1 |
Onchocerca volvulus | 0.0223 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 nM | Inhibition of SCD1 in mouse liver microsomes | ChEMBL. | 24370012 |
IC50 (binding) | = 137 nM | Inhibition of SCD1 in human HepG2 cells using radiolabeled stearic acid as substrate | ChEMBL. | 24370012 |
Inhibition (binding) | Inhibition of human delta-6 desaturase at 10 uM | ChEMBL. | 24370012 | |
Inhibition (binding) | Inhibition of human delta-5 desaturase at 10 uM | ChEMBL. | 24370012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.