Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.2472 | 1 | 0.5 |
Toxoplasma gondii | prostaglandin-E synthase | 0.2472 | 1 | 1 |
Onchocerca volvulus | 0.2472 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2472 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2472 | 1 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.2472 | 1 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.2472 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 61 % | Immunomodulatory activity in mouse assessed as reduction of IL-4 secretion at 10 ug/mL, iv relative to RCAI-147 | ChEMBL. | 24360828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.