Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotensin receptor 1 (high affinity) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0749 | 0.4696 | 0.4696 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0749 | 0.4696 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0749 | 0.4696 | 0.4696 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0749 | 0.4696 | 0.4696 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0407 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.0235 | 0.0235 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0749 | 0.4696 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0407 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.1155 | 1 | 1 |
Trypanosoma brucei | Prostaglandin E synthase | 0.1155 | 1 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1155 | 1 | 1 |
Onchocerca volvulus | 0.1155 | 1 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0749 | 0.4696 | 1 |
Toxoplasma gondii | prostaglandin-E synthase | 0.1155 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0407 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0407 | 0.0235 | 0.0235 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0407 | 0.0235 | 0.0235 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1155 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0407 | 0.0235 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1155 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0749 | 0.4696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.0235 | 0.0235 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0749 | 0.4696 | 0.4696 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0407 | 0.0235 | 0.0235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.3 uM | Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay | ChEMBL. | 24332089 |
Emax (binding) | = 93 % | Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay relative to NT peptide | ChEMBL. | 24332089 |
Stabilty (ADMET) | = 76 % | Metabolic stability in mouse plasma assessed as compound remaining at 3 hrs | ChEMBL. | 24332089 |
Stabilty (ADMET) | = 100 % | Metabolic stability in human liver microsomes assessed as compound remaining at 1 hr | ChEMBL. | 24332089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.