Detailed information for compound 182041

Basic information

Technical information
  • TDR Targets ID: 182041
  • Name: [5-[bis(2-hydroxyethyl)amino]-2-nitrophenyl]- morpholin-4-ylmethanone
  • MW: 339.344 | Formula: C15H21N3O6
  • H donors: 2 H acceptors: 5 LogP: -0.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(c1ccc(c(c1)C(=O)N1CCOCC1)[N+](=O)[O-])CCO
  • InChi: 1S/C15H21N3O6/c19-7-3-16(4-8-20)12-1-2-14(18(22)23)13(11-12)15(21)17-5-9-24-10-6-17/h1-2,11,19-20H,3-10H2
  • InChiKey: CCQJRJNXIZRUPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [5-[bis(2-hydroxyethyl)amino]-2-nitro-phenyl]-morpholino-methanone
  • [5-[bis(2-hydroxyethyl)amino]-2-nitrophenyl]-morpholinomethanone
  • [5-[bis(2-hydroxyethyl)amino]-2-nitro-phenyl]-morpholin-4-yl-methanone
  • [5-(bis(2-hydroxyethyl)amino)-2-nitrophenyl]-morpholin-4-ylmethanone
  • [5-(bis(2-hydroxyethyl)amino)-2-nitro-phenyl]-morpholino-methanone
  • [5-(bis(2-hydroxyethyl)amino)-2-nitrophenyl]-morpholinomethanone
  • [5-(bis(2-hydroxyethyl)amino)-2-nitro-phenyl]-morpholin-4-yl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0026 0.0026
Echinococcus granulosus c-Jun N-terminal kinases 0.0226 0.429 0.429
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni opsin-like receptor 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0026 0.0026
Echinococcus granulosus geminin 0.0168 0.3116 0.3116
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0026 0.0026
Brugia malayi neuropeptide F receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0026 0.0026
Trichomonas vaginalis rotamase, putative 0.0505 1 1
Echinococcus granulosus allatostatin A receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0026 0.0026
Echinococcus granulosus hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus orexin receptor type 2 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide receptor 0.0017 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni opsin-like receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0026 0.0026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0026 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0371 0.0371
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0505 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0026 0.0026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0371 0.0371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0154 0.2818 0.5
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0505 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis expressed protein 0.0505 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0026 0.0026
Schistosoma mansoni rotamase 0.0505 1 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0493 0.9757 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0026 0.0026
Brugia malayi G protein-coupled receptor 0.0017 0.0026 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0026 0.0026
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0493 0.9757 1
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0026 0.0026
Schistosoma mansoni amine GPCR 0.0017 0.0026 0.0026
Brugia malayi Stress-activated protein kinase jnk-1 0.0226 0.429 0.429
Echinococcus granulosus fmrfamide receptor 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0026 0.0026
Brugia malayi ORL1-like opioid receptor 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus g protein coupled receptor 0.0017 0.0026 0.0026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide receptor 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0026 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni amine GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0691 0.0691
Schistosoma mansoni hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi Serotonin receptor 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0691 0.0691
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis sex peptide receptor 0.0017 0.0026 0.0026
Brugia malayi Dopamine receptor protein 1 0.0017 0.0026 0.0026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0026 0.0026
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0026 0.0026
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0026 0.0026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0026 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0226 0.429 0.429
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0026 0.0026
Brugia malayi neuropeptide F receptor 0.0017 0.0026 0.0026
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0493 0.9757 1
Brugia malayi Dopamine receptor 0.0017 0.0026 0.0026
Brugia malayi G-protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0226 0.429 0.429
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine receptor 0.0017 0.0026 0.0026
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni amine GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus granulosus serotonin receptor 0.0017 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0168 0.3116 0.3116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus expressed protein 0.0505 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0168 0.3116 0.3116
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0026 0.0026
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis serotonin receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni amine GPCR 0.0017 0.0026 0.0026
Schistosoma mansoni histamine h1 receptor 0.0017 0.0026 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0026 0.0026
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus g protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0026 0.0026
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0026 0.0026
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0026 0.0026
Echinococcus multilocularis somatostatin receptor 0.0017 0.0026 0.0026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Brugia malayi Melatonin receptor type 1A 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni adenoreceptor 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0026 0.0026
Brugia malayi GnHR receptor homolog 0.0017 0.0026 0.0026
Brugia malayi Serotonin receptor 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis serotonin receptor 0.0017 0.0026 0.0026
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0026 0.0026
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0026 0.0026
Echinococcus granulosus g protein coupled receptor 0.0017 0.0026 0.0026
Brugia malayi RE15519p 0.0017 0.0026 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0691 0.0691
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0026 0.0026
Schistosoma mansoni opsin-like receptor 0.0017 0.0026 0.0026
Brugia malayi larval opioid receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0026 0.0026
Brugia malayi G-protein coupled receptor 0.0017 0.0026 0.0026
Brugia malayi Dopamine receptor protein 2 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0026 0.0026
Echinococcus multilocularis geminin 0.0168 0.3116 0.3116
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0026 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0026 0.0026
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0493 0.9757 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.429 0.429
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni biogenic amine receptor 0.0017 0.0026 0.0026
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Toxoplasma gondii peptidylprolyl isomerase 0.0493 0.9757 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Echinococcus granulosus sex peptide receptor 0.0017 0.0026 0.0026
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0026 0.5
Schistosoma mansoni biogenic amine receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0026 0.0026
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.8425 0.8425
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0026 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0691 0.0691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Schistosoma mansoni serine-type protease inhibitor 0.0428 0.8425 0.8425
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0493 0.9757 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0026 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0026 0.0026
Schistosoma mansoni myosin xvIII 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0026 0.0026
Brugia malayi sulfakinin receptor protein 0.0017 0.0026 0.0026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0026 0.0026
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0026 0.0026
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0026 0.0026
Echinococcus granulosus somatostatin receptor 0.0017 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0371 0.0371
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0026 0.0026
Schistosoma mansoni amine GPCR 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0017 0.0026 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0026 0.0026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0026 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0026 0.0026
Brugia malayi AKH receptor 0.0017 0.0026 0.0026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Brugia malayi putative neuropeptide receptor 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0026
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0026 0.0026

Activities

Activity type Activity value Assay description Source Reference
HF (functional) = 1 Hypersensitivity factor was defined as the ratio of IC50(AA8) to IC50(UV4) ChEMBL. 1507207
IC50 (functional) = 9200 uM Growth inhibition of aerobic chinese hamster ovary fibroblast UV4 cells using an exposure time of 18 hours ChEMBL. 1507207
IC50 (functional) = 11200 uM Growth inhibition of aerobic chinese hamster ovary fibroblast AA8 cell line using an exposure time of 18 hours ChEMBL. 1507207

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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