Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.9919 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0059 | 0.7525 | 0.7525 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.1472 | 0.981 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0072 | 0.9443 | 0.952 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0013 | 0.0468 | 0.0472 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0472 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.1472 | 0.981 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.9919 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0472 |
Brugia malayi | RNA binding protein | 0.0075 | 0.9919 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0072 | 0.9443 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.1472 | 0.1484 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.9919 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0013 | 0.0468 | 0.0472 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.1472 | 0.1484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.1472 | 0.1484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.1472 | 0.1484 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.952 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.1472 | 0.1484 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.1472 | 0.1484 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.9919 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.1472 | 0.1484 |
Loa Loa (eye worm) | ctsf protein | 0.002 | 0.1472 | 0.1062 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.9919 | 1 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.1472 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.9919 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.9919 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0069 | 0.8997 | 0.8997 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.9919 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Loa Loa (eye worm) | fibroinase | 0.002 | 0.1472 | 0.1062 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.9919 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0468 | 0.0472 |
Echinococcus granulosus | cathepsin l1 | 0.0013 | 0.0468 | 0.0472 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.1472 | 0.1062 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.1472 | 0.1484 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.1472 | 0.1062 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Onchocerca volvulus | 0.002 | 0.1491 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.1472 | 0.1484 |
Leishmania major | cathepsin L-like protease | 0.0075 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.1472 | 0.1484 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.9919 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.1472 | 0.1484 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.952 |
Leishmania major | cathepsin L-like protease | 0.0075 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.002 | 0.1472 | 0.1062 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.002 | 0.1472 | 0.1472 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.1472 | 0.1484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0072 | 0.9443 | 0.952 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0468 | 0.3182 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.9919 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.9919 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.1472 | 0.1484 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0075 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0072 | 0.9443 | 0.9347 |
Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.1472 | 0.981 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0468 | 0.3182 |
Onchocerca volvulus | 0.002 | 0.1472 | 0.981 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.1472 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1472 | 0.1062 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 0.9443 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0013 | 0.0468 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (binding) | = 0.06 ug ml-1 | Inhibition of Staphylococcus aureus ATCC 29213 FtsZ-mediated cell division phenotype | ChEMBL. | 24287381 |
Vd (ADMET) | = 2 L/Kg | Volume of distribution in Balb/c mouse at 3 mg/kg, iv by LC-MS/MS analysis | ChEMBL. | 24287381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.