Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | perforin 1 (pore forming protein) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | methionine aminopeptidase (map) | 0.0052 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0419 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0419 | 1 | 1 |
Mycobacterium ulcerans | cytoplasmic peptidase PepQ | 0.0052 | 0 | 0.5 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0419 | 1 | 1 |
Mycobacterium leprae | Probable cytoplasmic peptidase PepQ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | dipeptidase PepE | 0.0052 | 0 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0419 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0419 | 1 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0419 | 1 | 1 |
Mycobacterium tuberculosis | Dipeptidase PepE | 0.0052 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Xaa-Pro aminopeptidase | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0419 | 1 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0052 | 0 | 0.5 |
Treponema pallidum | aminopeptidase P | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytoplasmic peptidase PepQ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | dipeptidase | 0.0052 | 0 | 0.5 |
Chlamydia trachomatis | aminopeptidase P | 0.0052 | 0 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0052 | 0 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0419 | 1 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0419 | 1 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0419 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0052 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0052 | 0 | 0.5 |
Giardia lamblia | Methionine aminopeptidase | 0.0419 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0419 | 1 | 1 |
Mycobacterium ulcerans | aminopeptidase | 0.0052 | 0 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0419 | 1 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0419 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0419 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0419 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0419 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0419 | 1 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0419 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.52 uM | Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated for 30 mins followed by addition of cells measured after 4 hrs by gamma counting analysis | ChEMBL. | 24195776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.