Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0042 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3892 | 0.3892 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0042 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0042 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0042 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.7694 | 0.7694 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0042 | 1 | 1 |
Onchocerca volvulus | 0.0042 | 1 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.7694 | 0.7694 |
Leishmania major | cytochrome p450-like protein | 0.0036 | 0.7694 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0042 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0042 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0036 | 0.7694 | 0.7694 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0042 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.7694 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0042 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.7694 | 0.7694 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0042 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0036 | 0.7694 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0042 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0042 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0042 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.7694 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0036 | 0.7694 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0042 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0042 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0042 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.7694 | 0.7694 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 117 % | Inhibition of adenosine A2A receptor (unknown origin) at 100 umol/L relative to control | ChEMBL. | 24332624 |
Ki (binding) | = 52 nM | Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cells | ChEMBL. | 24332624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.