Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 644.88 uM | Antileishmanial activity against Leishmania donovani NHOM/IN/80/DD8 promastigotes assessed as decrease in parasite growth after 72 hrs by MTT assay | ChEMBL. | 24513045 |
MIC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli NCIM 2256 by standard agar method | ChEMBL. | 24513045 |
MIC (functional) | = 80 ug ml-1 | Antifungal activity against Candida albicans NCIM 3471 by standard agar method | ChEMBL. | 24513045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.