Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0098 | 0.0137 | 0.0137 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1528 | 0.6263 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0098 | 0.0137 | 0.014 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1528 | 0.6263 | 0.5 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0071 | 0.0022 | 0.0022 |
Brugia malayi | SRC-1 | 0.0098 | 0.0137 | 0.0212 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Brugia malayi | MAP kinase sur-1 | 0.1528 | 0.6263 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1528 | 0.6263 | 0.6263 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0098 | 0.0137 | 0.0137 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1528 | 0.6263 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1528 | 0.6263 | 0.6263 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0098 | 0.0137 | 0.0137 |
Schistosoma mansoni | adapter molecule crk | 0.0086 | 0.0085 | 0.0086 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1528 | 0.6263 | 0.6379 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0137 | 0.014 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Brugia malayi | Variant SH3 domain containing protein | 0.0086 | 0.0085 | 0.0128 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0071 | 0.0022 | 0.0022 |
Schistosoma mansoni | vav2 | 0.0067 | 0.0005 | 0.0005 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1528 | 0.6263 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0086 | 0.0085 | 0.0128 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0146 | 0.0341 | 0.0341 |
Brugia malayi | Variant SH3 domain containing protein | 0.0086 | 0.0085 | 0.0128 |
Entamoeba histolytica | p21-activated kinase | 0.0071 | 0.0022 | 0.2065 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0071 | 0.0022 | 0.0028 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1528 | 0.6263 | 1 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0071 | 0.0022 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1528 | 0.6263 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0137 | 0.014 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Trypanosoma brucei | protein kinase, putative | 0.1528 | 0.6263 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.0022 | 0.0028 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0086 | 0.0085 | 0.0086 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0022 | 0.2065 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0086 | 0.0085 | 0.0128 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.24 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0086 | 0.0085 | 0.0086 |
Onchocerca volvulus | 0.009 | 0.0102 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1528 | 0.6263 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0086 | 0.0085 | 0.0085 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0071 | 0.0022 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0098 | 0.0137 | 0.0137 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1528 | 0.6263 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0086 | 0.0085 | 0.0086 |
Entamoeba histolytica | protein kinase, putative | 0.0091 | 0.0107 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0098 | 0.0137 | 0.0212 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0098 | 0.0137 | 0.0137 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1528 | 0.6263 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0098 | 0.0137 | 0.0137 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0022 | 0.2065 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0137 | 0.014 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0098 | 0.0137 | 0.0137 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1528 | 0.6263 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2357 | 0.9818 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1528 | 0.6263 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0098 | 0.0137 | 0.0212 |
Echinococcus granulosus | NCK adaptor protein | 0.0086 | 0.0085 | 0.0085 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | NCK adaptor protein | 0.0086 | 0.0085 | 0.0085 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0098 | 0.0137 | 0.0137 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1528 | 0.6263 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0098 | 0.0137 | 0.0137 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1528 | 0.6263 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0091 | 0.0107 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0098 | 0.0137 | 0.0137 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1528 | 0.6263 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0085 | 0.0128 |
Echinococcus granulosus | c src tyrosine kinase | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1528 | 0.6263 | 0.6263 |
Entamoeba histolytica | protein kinase, putative | 0.0071 | 0.0022 | 0.2065 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0098 | 0.0137 | 0.0137 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0086 | 0.0085 | 0.0128 |
Schistosoma mansoni | nck2/grb4 | 0.0086 | 0.0085 | 0.0086 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0071 | 0.0022 | 0.0022 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0137 | 0.014 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0086 | 0.0085 | 0.0085 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0071 | 0.0022 | 0.0022 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0098 | 0.0137 | 0.0137 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1528 | 0.6263 | 0.6263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 111 uM | Inhibition of recombinant TDP1 (unknown origin) using N14Y as substrate after 15 mins by PAGE analysis | ChEMBL. | 24517248 |
Inhibition (binding) | = 75 % | Inhibition of recombinant topoisomerase-1 (unknown origin) assessed as inhibition of 3'-[32P]-labeled DNA cleavage at 0.1 to 100 uM after 20 mins by PAGE analysis relative to control | ChEMBL. | 24517248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.