Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pyogenes | Streptokinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0301 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Echinococcus multilocularis | enteropeptidase | 0.0301 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0301 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0301 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0301 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0301 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0301 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0301 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0301 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0301 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.19 uM | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma after 24 hrs by colorimetric analysis | ChEMBL. | 24559768 |
T/C (binding) | = 0.3 | Inhibition of Streptococcus pyogenes UMAA2616 streptokinase assessed as plasmin activity in human plasma at 5 uM after 24 hrs by colorimetric analysis relative to control | ChEMBL. | 24559768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.