Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | biotin protein ligase | 0.0343 | 0.0755 | 1 |
Giardia lamblia | Hypothetical protein | 0.0343 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0343 | 0.0755 | 0.5 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0311 | 0 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0343 | 0.0755 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0343 | 0.0755 | 0.5 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0732 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0343 | 0.0755 | 0.5 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0311 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0343 | 0.0755 | 1 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0343 | 0.0755 | 1 |
Chlamydia trachomatis | biotin synthetase | 0.0343 | 0.0755 | 1 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0701 | 0.9245 | 0.5 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0311 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.0343 | 0.0755 | 1 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0343 | 0.0755 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.0343 | 0.0755 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0343 | 0.0755 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0343 | 0.0755 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0343 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0343 | 0.0755 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 14 uM | Inhibitory activity against Angiotensin II receptor, from rat adrenal gland at a concentration of 10 uM | ChEMBL. | 1956044 |
Inhibition (binding) | = 14 uM | Inhibitory activity against Angiotensin II receptor, from rat adrenal gland at a concentration of 10 uM | ChEMBL. | 1956044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.