Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0772 | 0.0772 |
Loa Loa (eye worm) | hhat protein | 0.0187 | 0.0772 | 0.0772 |
Loa Loa (eye worm) | MBOAT family protein | 0.0187 | 0.0772 | 0.0772 |
Entamoeba histolytica | hypothetical protein | 0.0187 | 0.0772 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0187 | 0.0772 | 0.0772 |
Toxoplasma gondii | hypothetical protein | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0772 | 0.0772 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0187 | 0.0772 | 0.5 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0187 | 0.0772 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0187 | 0.0772 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.198 | 0.913 | 0.9057 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Onchocerca volvulus | 0.0187 | 0.0772 | 0.5 | |
Leishmania major | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0187 | 0.0772 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.2167 | 1 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.2167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0772 | 0.0772 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0187 | 0.0772 | 0.0772 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0187 | 0.0772 | 0.0772 |
Leishmania major | hypothetical protein, conserved | 0.0187 | 0.0772 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0187 | 0.0772 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0772 | 0.0772 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0187 | 0.0772 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0187 | 0.0772 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0187 | 0.0772 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0187 | 0.0772 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0187 | 0.0772 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0187 | 0.0772 | 0.5 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0187 | 0.0772 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0187 | 0.0772 | 0.0772 |
Trichomonas vaginalis | porcupine, putative | 0.0187 | 0.0772 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.2167 | 1 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.2167 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.198 | 0.913 | 0.9057 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0187 | 0.0772 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | In vitro inhibitory concentration against Selectin P in a cell-free binding assay | ChEMBL. | 9379443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.