TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 230.711 | Formula: C10H11ClO2S
H donors: 1 H acceptors: 2 LogP: 2.63 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: SCC(C(=O)O)Cc1ccc(cc1)Cl
InChi: 1S/C10H11ClO2S/c11-9-3-1-7(2-4-9)5-8(6-14)10(12)13/h1-4,8,14H,5-6H2,(H,12,13)
InChiKey: OZIHWAMUKLHUKO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Carboxypeptidase A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	potential zinc carboxypeptidase similar to S. cerevisiae ECM14	Carboxypeptidase A1	419 aa	361 aa	28.0 %
Echinococcus granulosus	subfamily M14A unassigned peptidase	Carboxypeptidase A1	419 aa	403 aa	32.3 %
Onchocerca volvulus	Vacuolar protein sorting-associated protein 51 homolog	Carboxypeptidase A1	419 aa	427 aa	34.0 %
Onchocerca volvulus		Carboxypeptidase A1	419 aa	448 aa	29.7 %
Echinococcus multilocularis	subfamily M14A unassigned peptidase	Carboxypeptidase A1	419 aa	422 aa	31.3 %
Onchocerca volvulus		Carboxypeptidase A1	419 aa	439 aa	30.5 %
Onchocerca volvulus	Replication factor C subunit 1 homolog	Carboxypeptidase A1	419 aa	441 aa	33.8 %
Drosophila melanogaster	CG4017 gene product from transcript CG4017-RA	Carboxypeptidase A1	419 aa	417 aa	35.5 %
Candida albicans	potential zinc carboxypeptidase similar to S. cerevisiae ECM14	Carboxypeptidase A1	419 aa	361 aa	28.0 %
Onchocerca volvulus		Carboxypeptidase A1	419 aa	422 aa	36.3 %
Schistosoma japonicum	ko:K01290 carboxypeptidase A [EC3.4.17.1], putative	Carboxypeptidase A1	419 aa	423 aa	31.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0056	0.653	0.7277
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.4872	0.543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.0068	0.8341	0.9297
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.4872	0.543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Brugia malayi	G protein-coupled receptor	0.0046	0.4872	0.543
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	neuropeptide receptor	0.0046	0.4872	0.4872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	serotonin receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	neuropeptide receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.4872	0.543
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.4872	0.543
Schistosoma mansoni	hypothetical protein	0.0046	0.4872	0.4872
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.4872	0.543
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0021	0.1028	0.1145
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	amine GPCR	0.0046	0.4872	0.4872
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.4872	0.4872
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.4872	0.4872
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.0068	0.8341	1
Brugia malayi	sulfakinin receptor protein	0.0046	0.4872	0.543
Echinococcus granulosus	sex peptide receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	serotonin receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.4872	0.543
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	g protein coupled receptor	0.0046	0.4872	0.543
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0021	0.1028	0.1145
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.4872	0.4872
Brugia malayi	Dopamine receptor protein 1	0.0046	0.4872	0.543
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.4872	0.543
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.4872	0.4872
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	somatostatin receptor	0.0046	0.4872	0.543
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.4872	0.4872
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.4872	0.543
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.4872	0.543
Echinococcus granulosus	g protein coupled receptor	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Schistosoma mansoni	amine GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0021	0.1028	0.1145
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	g protein coupled receptor	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.4872	0.543
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.4872	0.543
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.4872	0.543
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	voltage gated potassium channel	0.0021	0.1028	0.1145
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	putative neuropeptide receptor	0.0046	0.4872	0.543
Schistosoma mansoni	amine GPCR	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.4872	0.543
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0072	0.8972	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Schistosoma mansoni	amine GPCR	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0072	0.8972	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Schistosoma mansoni	histamine h1 receptor	0.0046	0.4872	0.4872
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.8236	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0072	0.8972	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0072	0.8972	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.4872	0.4872
Schistosoma mansoni	opsin-like receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.0068	0.8341	0.9297
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.4872	0.543
Brugia malayi	RE15519p	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0063	0.7495	0.8354
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0021	0.1028	0.1145
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.4872	0.543
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.4872	0.543
Brugia malayi	Dopamine receptor protein 2	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.4872	0.543
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.4872	0.543
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.4872	0.543
Brugia malayi	Serotonin receptor	0.0046	0.4872	0.543
Echinococcus granulosus	somatostatin receptor	0.0046	0.4872	0.543
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.4872	0.4872
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.0068	0.8341	0.8341
Schistosoma mansoni	hypothetical protein	0.0046	0.4872	0.4872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Schistosoma mansoni	biogenic amine receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Echinococcus granulosus	orexin receptor type 2	0.0046	0.4872	0.543
Echinococcus granulosus	allatostatin A receptor	0.0046	0.4872	0.543
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.4872	0.543
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.4872	0.543
Brugia malayi	Serotonin receptor	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.4872	0.4872
Brugia malayi	ORL1-like opioid receptor	0.0046	0.4872	0.543
Schistosoma mansoni	opsin-like receptor	0.0046	0.4872	0.4872
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	G-protein coupled receptor	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.4872	0.543
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide receptor	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Onchocerca volvulus		0.0068	0.8341	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.4872	0.543
Brugia malayi	G-protein coupled receptor	0.0046	0.4872	0.543
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.4872	0.543
Onchocerca volvulus		0.0068	0.8341	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.1028	0.1028
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	adenoreceptor	0.0046	0.4872	0.4872
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.4872	0.543
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.4872	0.543
Brugia malayi	GnHR receptor homolog	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.4872	0.543
Onchocerca volvulus		0.0068	0.8341	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.4872	0.4872
Schistosoma mansoni	amine GPCR	0.0046	0.4872	0.4872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	larval opioid receptor	0.0046	0.4872	0.543
Onchocerca volvulus		0.0068	0.8341	1
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.4872	0.543
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Echinococcus granulosus	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	Melatonin receptor type 1A	0.0046	0.4872	0.543
Brugia malayi	AKH receptor	0.0046	0.4872	0.543
Brugia malayi	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	sex peptide receptor	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.4872	0.543
Echinococcus granulosus	fmrfamide receptor	0.0046	0.4872	0.543
Brugia malayi	Dopamine receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.4872	0.543
Schistosoma mansoni	neuropeptide receptor	0.0046	0.4872	0.4872
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.4872	0.4872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.8236	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.4872	0.4872
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.4872	0.543
Brugia malayi	neuropeptide F receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.4872	0.543
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.4872	0.543
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.1028	0.1028
Brugia malayi	neuropeptide F receptor	0.0046	0.4872	0.543
Echinococcus granulosus	serotonin receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.4872	0.543
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.4872	0.543
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.4872	0.543
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.4872	0.543
Schistosoma mansoni	biogenic amine receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.4872	0.543
Schistosoma mansoni	hypothetical protein	0.0046	0.4872	0.4872
Schistosoma mansoni	opsin-like receptor	0.0046	0.4872	0.4872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.4872	0.543
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Schistosoma mansoni	neuropeptide receptor	0.0046	0.4872	0.4872
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.4872	0.543
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.4872	0.543
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.4872	0.543
Schistosoma mansoni	hypothetical protein	0.0046	0.4872	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.4872	0.543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.4872	0.543
Echinococcus granulosus	voltage gated potassium channel	0.0021	0.1028	0.1145
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.4872	0.4872
Schistosoma mansoni	voltage-gated potassium channel	0.0079	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.4872	0.4872
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.4872	0.543
Schistosoma mansoni	myosin xvIII	0.0046	0.4872	0.4872
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.4872	0.543
Loa Loa (eye worm)	hypothetical protein	0.0046	0.4872	0.543
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.4872	0.543

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 160 nM	Compound was evaluated for binding affinity against carboxypeptidase A (CPA), expressed as inhibitory constant (Ki)	ChEMBL.	No reference
Ki (binding)	= 160 nM	Compound was evaluated for binding affinity against carboxypeptidase A (CPA), expressed as inhibitory constant (Ki)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 182427